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Study · Animal study (in vivo) · rat · 2009

1 result

[Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA].

Semenova TP, kozlovskiĭ II, Zakharova NM, Kozlovskaia MM

Eksperimental'naia i klinicheskaia farmakologiia1 Jul 2009Cited by 1 (Europe PMC)

PMID19803361 (opens in a new tab)PepBankPUB-19803361
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In Wistar rats pretreated with PCPA, selank enhanced serotonin metabolism in the brain stem 30 min after injection.

    In plain wordsIn rats with lowered serotonin synthesis, selank increased serotonin turnover in the brain stem 30 minutes after injection.

    Peptide
    Selank
    Outcome
    IncreaseSerotonin metabolism in brain stem 30 min after injection
    Study

    ratn: not reported in source

    Wistar rats pretreated with PCPA
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It is established that selank enhances the 5-HT metabolism in the brain stem 30 min after injection to animals pretreated with PCPA.
    1 context sentence
    Summary · context
    Effects of the peptide drugs selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) and tuftsin (Thr-Lys-Pro-Arg) on the metabolism of serotonin (5-hydroxytryptamine, 5-HT) in the brain of Wistar rats preliminarily treated with the 5-HT-synthesis inhibitor p-chlorophenylalanine (PCPA, 320 mg/kg, i.p., 4 days before e…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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