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Study · Animal study (in vivo) · rat · 2009

5 results

Therapeutic efficacy of vasoactive intestinal peptide in escherichia coli lipopolysaccharide-induced experimental periodontitis in rats.

Gürkan A, Emingil G, Nizam N, Doğanavşargil B, Sezak M, Kütükçüler N, Atilla G

Journal of periodontology1 Oct 2009Cited by 23 (Europe PMC)

PMID19792856 (opens in a new tab)DOI10.1902/jop.2009.090031 (opens in a new tab)PepBankPUB-19792856
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with LPS-induced periodontitis, VIP caused a dose-dependent decline in alveolar bone loss compared with LPS alone, but the differences were not significant.

    In plain wordsIn rats with gum disease, VIP lowered bone loss in a dose-linked way, but the difference from rats given only LPS was not significant.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeAlveolar bone loss
    Study

    ratn = 63

    E. coli LPS-induced experimental periodontitis (male Sprague-Dawley)
    Comparator
    LPS group
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.1, 1 and 10 nmol · intraperitoneal · injections on days 2, 4, 6, 8 and 10As given in this study (rat).

    Source sentences

    Summary
    The application of VIP caused a dose-dependent decline in alveolar bone loss compared to the LPS group, but the differences were not significant (P >0.05).
    1 context sentence
    Summary · context
    Sixty-three male Sprague-Dawley rats were divided into five groups: control; lipopolysaccharide (LPS); LPS + 0.1 nmol VIP; LPS + 1 nmol VIP; and LPS + 10 nmol VIP.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with LPS-induced periodontitis, histologic findings of inflammation were reduced in all VIP groups.

    In plain wordsIn rats with gum disease, tissue signs of inflammation were lower in all VIP-treated groups.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseHistologic inflammation
    Study

    ratn = 63

    E. coli LPS-induced experimental periodontitis (male Sprague-Dawley)
    Comparator
    LPS group
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    0.1, 1 and 10 nmol · intraperitoneal · injections on days 2, 4, 6, 8 and 10As given in this study (rat).

    Source sentences

    Summary
    A reduction in the histologic findings of inflammation was observed in all VIP groups.
    1 context sentence
    Summary · context
    Sixty-three male Sprague-Dawley rats were divided into five groups: control; lipopolysaccharide (LPS); LPS + 0.1 nmol VIP; LPS + 1 nmol VIP; and LPS + 10 nmol VIP.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with LPS-induced periodontitis, the 1- and 10-nmol VIP groups had significantly lower serum sRANKL than the LPS group.

    In plain wordsIn rats with gum disease, blood sRANKL, a bone-loss signal, was lower with 1 and 10 nmol VIP than with LPS alone.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseSerum sRANKL
    Study

    ratn: not reported in source

    E. coli LPS-induced experimental periodontitis (male Sprague-Dawley)
    Comparator
    LPS group
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    1 and 10 nmol · intraperitoneal · injections on days 2, 4, 6, 8 and 10As given in this study (rat).

    Source sentences

    Summary
    The 1- and 10-nmol VIP groups showed significantly lower serum sRANKL and OPG levels compared to the LPS group (P <0.05).
    1 context sentence
    Summary · context
    Sixty-three male Sprague-Dawley rats were divided into five groups: control; lipopolysaccharide (LPS); LPS + 0.1 nmol VIP; LPS + 1 nmol VIP; and LPS + 10 nmol VIP.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with LPS-induced periodontitis, the 1- and 10-nmol VIP groups had significantly lower serum OPG than the LPS group.

    In plain wordsIn rats with gum disease, blood OPG was lower with 1 and 10 nmol VIP than with LPS alone.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseSerum OPG
    Study

    ratn: not reported in source

    E. coli LPS-induced experimental periodontitis (male Sprague-Dawley)
    Comparator
    LPS group
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    1 and 10 nmol · intraperitoneal · injections on days 2, 4, 6, 8 and 10As given in this study (rat).

    Source sentences

    Summary
    The 1- and 10-nmol VIP groups showed significantly lower serum sRANKL and OPG levels compared to the LPS group (P <0.05).
    1 context sentence
    Summary · context
    Sixty-three male Sprague-Dawley rats were divided into five groups: control; lipopolysaccharide (LPS); LPS + 0.1 nmol VIP; LPS + 1 nmol VIP; and LPS + 10 nmol VIP.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with LPS-induced periodontitis, the number of vessels staining positive for endothelial OPG was greater in the 1-nmol VIP group than in the LPS group.

    In plain wordsIn rats with gum disease, more blood vessels in gum tissue showed OPG with 1 nmol VIP than with LPS alone.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseEndothelial OPG-positive vessels
    Study

    ratn: not reported in source

    E. coli LPS-induced experimental periodontitis (male Sprague-Dawley)
    Comparator
    LPS group
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    1 nmol · intraperitoneal · injections on days 2, 4, 6, 8 and 10As given in this study (rat).

    Source sentences

    Summary
    The number of positively stained vessels for endothelial OPG was greater in the 1-nmol VIP group than in the LPS group (P <0.05).
    1 context sentence
    Summary · context
    Sixty-three male Sprague-Dawley rats were divided into five groups: control; lipopolysaccharide (LPS); LPS + 0.1 nmol VIP; LPS + 1 nmol VIP; and LPS + 10 nmol VIP.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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