In rats with ischemic prefrontal cortex lesions, chronic intranasal Semax during the first six days after photothrombosis led to recovery of learning ability.
In plain wordsIn rats with brain lesions, nasal Semax given for six days after injury led to recovery of learning ability.
- Peptide
- Semax
- Outcome
- IncreaseRecovery of spatial learning in Morris water maze
- Study
ratn: not reported in source
Photothrombotic ischemic lesion of the prefrontal cortex- Outcome group
- Cognition and memory · Nervous system and cognition
- Studied dose
- 250 microg/kg/day · intranasal · first six days after photothrombosisAs given in this study (rat).
Source sentences
Chronic intranasal administration of the peptide Met-Glu-His-Phe-Pro-Gly-Pro (Semax), a synthetic analog of ACTH(4-7), at a dose of 250 microg/kg/day during the first six days after photothrombosis, led to recovery of the animals' learning ability.
1 context sentence(design, population, supporting numbers)
Photochemically induced thrombosis of blood vessels in the prefrontal cortex in rats was shown to lead to ischemic infarcts in the lesion zone. Bilateral ischemic lesioning of the prefrontal cortex degraded measures of spatial memory when animals were tested in a Morris water maze with an invisible…