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Study · Measured the body's own peptide · 2010

3 results

Changes in the expression of insulin-like growth factor 1 variants in the postnatal brain development and in neonatal hypoxia-ischaemia.

Beresewicz M, Majewska M, Makarewicz D, Vayro S, Zabłocka B, Górecki DC

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience18 Sept 2009Cited by 21 (Europe PMC)

PMID19766709 (opens in a new tab)DOI10.1016/j.ijdevneu.2009.09.002 (opens in a new tab)PepBankPUB-19766709
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In normal rats, IGF-1Ec was expressed during postnatal brain development with a specific temporal distribution.

    In plain wordsIn rats, the body's own IGF-1Ec (MGF) was present in the developing brain at specific ages.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableIGF-1Ec expression in normal postnatal brain development
    Study

    ratn: not reported in source

    Normal and neonatal hypoxia-ischaemia rat brain
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Both IGF-1Ea and IGF-1Ec are expressed during normal postnatal brain development, albeit with highly specific temporal distributions.
    1 context sentence
    Summary · context
    We have identified specific changes in the expression patterns of these IGF-1 variants in brain development in normal rats and following neonatal hypoxia-ischaemia (HI).

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In neonatal rats, hypoxia-ischaemia produced increased and prolonged expression of the IGF-1Ec isoform only.

    In plain wordsIn rats, brain injury from low oxygen raised and prolonged the body's own IGF-1Ec (MGF) levels in the brain.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseIGF-1Ec expression after neonatal hypoxia-ischaemia
    Study

    ratn: not reported in source

    Normal and neonatal hypoxia-ischaemia rat brain
    Comparator
    Normal rats
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    In contrast, HI produced increased and prolonged expression of the IGF-1Ec isoform only.
    1 context sentence
    Summary · context
    We have identified specific changes in the expression patterns of these IGF-1 variants in brain development in normal rats and following neonatal hypoxia-ischaemia (HI).

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In neonatal rats, hypoxia alone also stimulated expression of IGF-1Ec.

    In plain wordsIn rats, low oxygen alone also raised the body's own IGF-1Ec (MGF) levels in the brain.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseIGF-1Ec expression after hypoxia alone
    Study

    ratn: not reported in source

    Normal and neonatal hypoxia-ischaemia rat brain
    Comparator
    Normoxia
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Importantly, hypoxia alone stimulated the expression of IGF-1Ec as well.
    1 context sentence
    Summary · context
    We have identified specific changes in the expression patterns of these IGF-1 variants in brain development in normal rats and following neonatal hypoxia-ischaemia (HI).

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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