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Study · Animal study (in vivo) · mouse · 2009

5 results

Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues.

Toda C, Shiuchi T, Lee S, Yamato-Esaki M, Fujino Y, Suzuki A, Okamoto S, Minokoshi Y

Diabetes14 Sept 2009Cited by 95 (Europe PMC)

PMID19752162 (opens in a new tab)PMCIDPMC2780865 (opens in a new tab)DOI10.2337/db09-0638 (opens in a new tab)PepBankPUB-19752162
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, MT-II injected into the ventromedial hypothalamus or intracerebroventricularly increased glucose uptake in skeletal muscle.

    In plain wordsIn mice, MT-II injected into the brain increased glucose uptake in skeletal muscle.

    Peptide
    Melanotan II
    Outcome
    IncreaseGlucose uptake in skeletal muscle after MT-II (VMH or intracerebroventricular)
    Study

    mousen: not reported in source

    in vivo, freely moving mice
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · injection into hypothalamic nuclei or lateral ventricleAs given in this study (mouse).

    Source sentences

    Summary
    Injection of MT-II either into the VMH or intracerebroventricularly increased glucose uptake in skeletal muscle, BAT, and heart
    2 context sentences
    Summary · context
    Leptin or MT-II was injected into the ventromedial (VMH), dorsomedial (DMH), arcuate nucleus (ARC), or paraventricular (PVH) hypothalamus or the lateral ventricle (intracerebroventricularly) in freely moving mice.
    Summary · context
    Glucose uptake was measured by the 2-[(3)H]deoxy-d-glucose method.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, MT-II injected into the ventromedial hypothalamus or intracerebroventricularly increased glucose uptake in brown adipose tissue.

    In plain wordsIn mice, MT-II injected into the brain increased glucose uptake in brown fat.

    Peptide
    Melanotan II
    Outcome
    IncreaseGlucose uptake in brown adipose tissue after MT-II (VMH or intracerebroventricular)
    Study

    mousen: not reported in source

    in vivo, freely moving mice
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · injection into hypothalamic nuclei or lateral ventricleAs given in this study (mouse).

    Source sentences

    Summary
    Injection of MT-II either into the VMH or intracerebroventricularly increased glucose uptake in skeletal muscle, BAT, and heart
    2 context sentences
    Summary · context
    Leptin or MT-II was injected into the ventromedial (VMH), dorsomedial (DMH), arcuate nucleus (ARC), or paraventricular (PVH) hypothalamus or the lateral ventricle (intracerebroventricularly) in freely moving mice.
    Summary · context
    Glucose uptake was measured by the 2-[(3)H]deoxy-d-glucose method.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, MT-II injected into the ventromedial hypothalamus or intracerebroventricularly increased glucose uptake in the heart.

    In plain wordsIn mice, MT-II injected into the brain increased glucose uptake in the heart.

    Peptide
    Melanotan II
    Outcome
    IncreaseGlucose uptake in heart after MT-II (VMH or intracerebroventricular)
    Study

    mousen: not reported in source

    in vivo, freely moving mice
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · injection into hypothalamic nuclei or lateral ventricleAs given in this study (mouse).

    Source sentences

    Summary
    Injection of MT-II either into the VMH or intracerebroventricularly increased glucose uptake in skeletal muscle, BAT, and heart
    2 context sentences
    Summary · context
    Leptin or MT-II was injected into the ventromedial (VMH), dorsomedial (DMH), arcuate nucleus (ARC), or paraventricular (PVH) hypothalamus or the lateral ventricle (intracerebroventricularly) in freely moving mice.
    Summary · context
    Glucose uptake was measured by the 2-[(3)H]deoxy-d-glucose method.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice, MT-II injected into the paraventricular hypothalamus increased glucose uptake in brown adipose tissue.

    In plain wordsIn mice, MT-II injected into one brain region increased glucose uptake in brown fat.

    Peptide
    Melanotan II
    Outcome
    IncreaseGlucose uptake in brown adipose tissue after MT-II (PVH)
    Study

    mousen: not reported in source

    in vivo, freely moving mice
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · injection into hypothalamic nuclei or lateral ventricleAs given in this study (mouse).

    Source sentences

    Summary
    whereas that into the PVH increased glucose uptake in BAT
    2 context sentences
    Summary · context
    Leptin or MT-II was injected into the ventromedial (VMH), dorsomedial (DMH), arcuate nucleus (ARC), or paraventricular (PVH) hypothalamus or the lateral ventricle (intracerebroventricularly) in freely moving mice.
    Summary · context
    Glucose uptake was measured by the 2-[(3)H]deoxy-d-glucose method.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice, MT-II injected into the dorsomedial hypothalamus or the arcuate nucleus had no effect on glucose uptake in peripheral tissues.

    In plain wordsIn mice, MT-II injected into two other brain regions did not change glucose uptake in body tissues.

    Peptide
    Melanotan II
    Outcome
    No significant changeGlucose uptake after MT-II (DMH or ARC)
    Study

    mousen: not reported in source

    in vivo, freely moving mice
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · injection into hypothalamic nuclei or lateral ventricleAs given in this study (mouse).

    Source sentences

    Summary
    that into the DMH or ARC had no effect.
    2 context sentences
    Summary · context
    Leptin or MT-II was injected into the ventromedial (VMH), dorsomedial (DMH), arcuate nucleus (ARC), or paraventricular (PVH) hypothalamus or the lateral ventricle (intracerebroventricularly) in freely moving mice.
    Summary · context
    Glucose uptake was measured by the 2-[(3)H]deoxy-d-glucose method.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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