Stimulatory effect of growth hormone-releasing hormone (GHRH(1-29)NH2) on the proliferation, VEGF and chromogranin A secretion by human neuroendocrine tumor cell line NCI-H727 in vitro.

Stepień T, Sacewicz M, Lawnicka H, Krupiński R, Komorowski J, Siejka A, Stepień H

Neuropeptides10 Sept 2009Cited by 10 (Europe PMC)

PMID19747727DOI10.1016/j.npep.2009.08.005PepBankPUB-19747727

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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In human bronchial neuroendocrine tumor NCI-H727 cells, GHRH(1-29)NH2 increased cell proliferation in vitro.
In plain wordsIn lab-grown human lung tumor cells, GHRH(1-29)NH2 made the cells multiply more.
Peptide
Sermorelin
Outcome
IncreaseCell proliferation
Study
humann: not reported in source
NCI-H727 human bronchial neuroendocrine tumor cell line
Outcome group
Tumor growth · Cancer
Studied dose
10(-8)-10(-6)MAs given in this study (human).
Source sentences
Summary
GHRH(1-29)NH2 at the concentrations of 10(-8)-10(-6)M increased the proliferation of these cells and this effect was associated with a statistically significant increase in VEGF and chromogranin A secretion into the supernatants of the tested cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated for the first time the in vitro effect of GHRH(1-29)NH2 on the proliferation and the secretion of vascular endothelial growth factor (VEGF) and chromogranin A by the human bronchial neuroendocrine tumor cells NCI-H727.
Report a problemFND-1974772701
02LabIn vitro (cells)Activity measurement
In human bronchial neuroendocrine tumor NCI-H727 cells, GHRH(1-29)NH2 significantly increased VEGF secretion into the supernatant.
In plain wordsIn lab-grown human lung tumor cells, GHRH(1-29)NH2 raised the amount of VEGF the cells released.
Peptide
Sermorelin
Outcome
IncreaseVEGF secretion
Study
humann: not reported in source
NCI-H727 human bronchial neuroendocrine tumor cell line
Outcome group
Tumor growth · Cancer
Studied dose
10(-8)-10(-6)MAs given in this study (human).
Source sentences
Summary
GHRH(1-29)NH2 at the concentrations of 10(-8)-10(-6)M increased the proliferation of these cells and this effect was associated with a statistically significant increase in VEGF and chromogranin A secretion into the supernatants of the tested cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated for the first time the in vitro effect of GHRH(1-29)NH2 on the proliferation and the secretion of vascular endothelial growth factor (VEGF) and chromogranin A by the human bronchial neuroendocrine tumor cells NCI-H727.
Report a problemFND-1974772702
03LabIn vitro (cells)Activity measurement
In human bronchial neuroendocrine tumor NCI-H727 cells, GHRH(1-29)NH2 significantly increased chromogranin A secretion into the supernatant.
In plain wordsIn lab-grown human lung tumor cells, GHRH(1-29)NH2 raised the amount of chromogranin A the cells released.
Peptide
Sermorelin
Outcome
IncreaseChromogranin A secretion
Study
humann: not reported in source
NCI-H727 human bronchial neuroendocrine tumor cell line
Outcome group
Tumor growth · Cancer
Studied dose
10(-8)-10(-6)MAs given in this study (human).
Source sentences
Summary
GHRH(1-29)NH2 at the concentrations of 10(-8)-10(-6)M increased the proliferation of these cells and this effect was associated with a statistically significant increase in VEGF and chromogranin A secretion into the supernatants of the tested cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated for the first time the in vitro effect of GHRH(1-29)NH2 on the proliferation and the secretion of vascular endothelial growth factor (VEGF) and chromogranin A by the human bronchial neuroendocrine tumor cells NCI-H727.
Report a problemFND-1974772703

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Version history

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Version 2Current
10 Oct 2026, 10:21 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

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