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Study · Not a test of the peptide alone · 2009

14 results

C-terminal mechano growth factor protects dopamine neurons: a novel peptide that induces heme oxygenase-1.

Quesada A, Micevych P, Handforth A

Experimental neurology6 Sept 2009Cited by 33 (Europe PMC)

PMID19735655 (opens in a new tab)DOI10.1016/j.expneurol.2009.08.029 (opens in a new tab)PepBankPUB-19735655
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone14

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

  1. 01AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome

    In 6-OHDA-lesioned rats, central or peripheral MGF24 protected against the development of contralateral forelimb under-utilization.

    In plain wordsIn rats with a Parkinson-like lesion, the MGF fragment MGF24 reduced the loss of use of one front limb.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseContralateral forelimb under-utilization
    Study

    ratn: not reported in source

    6-OHDA-lesioned rats
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    In 6-OHDA-lesioned rats, central or peripheral MGF24 administration protects against the development of contralateral forelimb under-utilization, reduces ipsilateral nigral DA cell body loss, and attenuates tyrosine hydroxylase fiber loss in the ipsilateral striatum, independent of IGF-1 receptor activation.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  2. 02AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome

    In 6-OHDA-lesioned rats, central or peripheral MGF24 reduced ipsilateral nigral dopamine cell body loss.

    In plain wordsIn rats with a Parkinson-like lesion, the MGF fragment MGF24 reduced the loss of dopamine cells on the lesioned side.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseIpsilateral nigral dopamine cell body loss
    Study

    ratn: not reported in source

    6-OHDA-lesioned rats
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    In 6-OHDA-lesioned rats, central or peripheral MGF24 administration protects against the development of contralateral forelimb under-utilization, reduces ipsilateral nigral DA cell body loss, and attenuates tyrosine hydroxylase fiber loss in the ipsilateral striatum, independent of IGF-1 receptor activation.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  3. 03AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome

    In 6-OHDA-lesioned rats, central or peripheral MGF24 attenuated tyrosine hydroxylase fiber loss in the ipsilateral striatum.

    In plain wordsIn rats with a Parkinson-like lesion, the MGF fragment MGF24 reduced the loss of dopamine nerve fibers in the striatum.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseTyrosine hydroxylase fiber loss in ipsilateral striatum
    Study

    ratn: not reported in source

    6-OHDA-lesioned rats
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    In 6-OHDA-lesioned rats, central or peripheral MGF24 administration protects against the development of contralateral forelimb under-utilization, reduces ipsilateral nigral DA cell body loss, and attenuates tyrosine hydroxylase fiber loss in the ipsilateral striatum, independent of IGF-1 receptor activation.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  4. 04AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Mechanism

    In 6-OHDA-lesioned rats, the protection by MGF24 was independent of IGF-1 receptor activation.

    In plain wordsIn rats with a Parkinson-like lesion, the protection from the MGF fragment MGF24 did not depend on the IGF-1 receptor.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableRole of IGF-1 receptor activation in MGF24 protection
    Study

    ratn: not reported in source

    6-OHDA-lesioned rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    In 6-OHDA-lesioned rats, central or peripheral MGF24 administration protects against the development of contralateral forelimb under-utilization, reduces ipsilateral nigral DA cell body loss, and attenuates tyrosine hydroxylase fiber loss in the ipsilateral striatum, independent of IGF-1 receptor activation.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  5. 05AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Mechanism

    In 6-OHDA-lesioned rats, peripheral MGF24 administration upregulated HO-1 expression in striatal and midbrain tissue.

    In plain wordsIn rats with a Parkinson-like lesion, the MGF fragment MGF24 given by a peripheral route raised HO-1 in brain tissue.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseHO-1 expression in striatal and midbrain tissue
    Study

    ratn: not reported in source

    6-OHDA-lesioned rats
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Peripheral MGF24 administration upregulates HO-1 expression in striatal and midbrain tissue.
    1 context sentence
    Summary · context
    In 6-OHDA-lesioned rats, central or peripheral MGF24 administration protects against the development of contralateral forelimb under-utilization, reduces ipsilateral nigral DA cell body loss, and attenuates tyrosine hydroxylase fiber loss in the ipsilateral striatum, independent of IGF-1 receptor activation.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  6. 06LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism

    In SH-SY5Y cells, the MGF C-terminal peptide MGF24 upregulated heme oxygenase-1 expression.

    In plain wordsIn cells in the lab, the MGF fragment MGF24 raised heme oxygenase-1, a cell defense protein.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseHO-1 expression
    Study

    n: not reported in source

    SH-SY5Y cells
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    We show that a short 24-amino acid C-terminal peptide of MGF (MGF24) upregulates heme oxygenase-1 (HO-1) expression and protects SH-SY5Y cells against apoptosis and cell loss induced by three DA cell-specific neurotoxins: 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenylpyridinium (MPP(+)), and rotenone.
    1 context sentence
    Summary · context
    To assess potential efficacy of mechano growth factor (MGF) for chronic neurodegenerative disorders, we studied whether MGF protects dopamine (DA) neurons subjected to neurotoxic stress.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  7. 07LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Efficacy outcome

    In SH-SY5Y cells, MGF24 protected against apoptosis and cell loss induced by 6-hydroxydopamine.

    In plain wordsIn cells in the lab, the MGF fragment MGF24 protected against cell death caused by the toxin 6-OHDA.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseApoptosis and cell loss induced by 6-OHDA
    Study

    n: not reported in source

    SH-SY5Y cells
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    We show that a short 24-amino acid C-terminal peptide of MGF (MGF24) upregulates heme oxygenase-1 (HO-1) expression and protects SH-SY5Y cells against apoptosis and cell loss induced by three DA cell-specific neurotoxins: 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenylpyridinium (MPP(+)), and rotenone.
    1 context sentence
    Summary · context
    To assess potential efficacy of mechano growth factor (MGF) for chronic neurodegenerative disorders, we studied whether MGF protects dopamine (DA) neurons subjected to neurotoxic stress.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  8. 08LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Efficacy outcome

    In SH-SY5Y cells, MGF24 protected against apoptosis and cell loss induced by 1-methyl-4-phenylpyridinium.

    In plain wordsIn cells in the lab, the MGF fragment MGF24 protected against cell death caused by the toxin MPP+.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseApoptosis and cell loss induced by MPP+
    Study

    n: not reported in source

    SH-SY5Y cells
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    We show that a short 24-amino acid C-terminal peptide of MGF (MGF24) upregulates heme oxygenase-1 (HO-1) expression and protects SH-SY5Y cells against apoptosis and cell loss induced by three DA cell-specific neurotoxins: 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenylpyridinium (MPP(+)), and rotenone.
    1 context sentence
    Summary · context
    To assess potential efficacy of mechano growth factor (MGF) for chronic neurodegenerative disorders, we studied whether MGF protects dopamine (DA) neurons subjected to neurotoxic stress.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  9. 09LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Efficacy outcome

    In SH-SY5Y cells, MGF24 protected against apoptosis and cell loss induced by rotenone.

    In plain wordsIn cells in the lab, the MGF fragment MGF24 protected against cell death caused by the toxin rotenone.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseApoptosis and cell loss induced by rotenone
    Study

    n: not reported in source

    SH-SY5Y cells
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    We show that a short 24-amino acid C-terminal peptide of MGF (MGF24) upregulates heme oxygenase-1 (HO-1) expression and protects SH-SY5Y cells against apoptosis and cell loss induced by three DA cell-specific neurotoxins: 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenylpyridinium (MPP(+)), and rotenone.
    1 context sentence
    Summary · context
    To assess potential efficacy of mechano growth factor (MGF) for chronic neurodegenerative disorders, we studied whether MGF protects dopamine (DA) neurons subjected to neurotoxic stress.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  10. 10LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism

    In SH-SY5Y cells exposed to 6-OHDA, MPP(+) and rotenone, MGF24 maintained the mitochondrial membrane potential.

    In plain wordsIn cells in the lab exposed to toxins, the MGF fragment MGF24 maintained the mitochondrial membrane potential.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableMitochondrial membrane potential under neurotoxins
    Study

    n: not reported in source

    SH-SY5Y cells
    Outcome group
    Mitochondrial function · Nervous system and cognition

    Source sentences

    Summary
    MGF24 maintains the mitochondrial membrane potential and blocks the release of mitochondrial apoptotic-inducing factor into the cytoplasm induced by 6-OHDA, MPP(+), and rotenone.
    1 context sentence
    Summary · context
    To assess potential efficacy of mechano growth factor (MGF) for chronic neurodegenerative disorders, we studied whether MGF protects dopamine (DA) neurons subjected to neurotoxic stress.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  11. 11LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism

    In SH-SY5Y cells, MGF24 blocked the release of mitochondrial apoptotic-inducing factor into the cytoplasm induced by 6-OHDA, MPP(+) and rotenone.

    In plain wordsIn cells in the lab exposed to toxins, the MGF fragment MGF24 blocked the release of a cell-death factor from mitochondria.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseRelease of mitochondrial apoptotic-inducing factor into the cytoplasm
    Study

    n: not reported in source

    SH-SY5Y cells
    Outcome group
    Mitochondrial function · Nervous system and cognition

    Source sentences

    Summary
    MGF24 maintains the mitochondrial membrane potential and blocks the release of mitochondrial apoptotic-inducing factor into the cytoplasm induced by 6-OHDA, MPP(+), and rotenone.
    1 context sentence
    Summary · context
    To assess potential efficacy of mechano growth factor (MGF) for chronic neurodegenerative disorders, we studied whether MGF protects dopamine (DA) neurons subjected to neurotoxic stress.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  12. 12LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism

    In SH-SY5Y cells, chemical inhibition of HO-1 with zinc protoporphyrin-IX prevented MGF24 neuroprotection against the three neurotoxins.

    In plain wordsIn cells in the lab, blocking HO-1 removed the protection that the MGF fragment MGF24 gave against three toxins.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableEffect of HO-1 inhibition on MGF24 neuroprotection
    Study

    n: not reported in source

    SH-SY5Y cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Chemical inhibition of HO-1 with zinc protoporphyrin-IX prevents neuroprotection by MGF24 against the three neurotoxins.
    1 context sentence
    Summary · context
    To assess potential efficacy of mechano growth factor (MGF) for chronic neurodegenerative disorders, we studied whether MGF protects dopamine (DA) neurons subjected to neurotoxic stress.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  13. 13LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism

    In SH-SY5Y cells, MGF24 did not activate Akt signaling.

    In plain wordsIn cells in the lab, the MGF fragment MGF24 did not switch on the Akt signal.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeAkt signaling activation by MGF24
    Study

    n: not reported in source

    SH-SY5Y cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    MGF24 does not activate Akt signaling
    1 context sentence
    Summary · context
    To assess potential efficacy of mechano growth factor (MGF) for chronic neurodegenerative disorders, we studied whether MGF protects dopamine (DA) neurons subjected to neurotoxic stress.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  14. 14LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism

    In SH-SY5Y cells, Akt inhibition did not block the protection by MGF24.

    In plain wordsIn cells in the lab, blocking Akt did not remove the protection given by the MGF fragment MGF24.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeEffect of Akt inhibition on MGF24 protection
    Study

    n: not reported in source

    SH-SY5Y cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    nor does Akt inhibition block MGF24 protection of SH-SY5Y cells.
    2 context sentences
    Summary · context
    MGF24 does not activate Akt signaling
    Summary · context
    To assess potential efficacy of mechano growth factor (MGF) for chronic neurodegenerative disorders, we studied whether MGF protects dopamine (DA) neurons subjected to neurotoxic stress.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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