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Study · Measured the body's own peptide · 2009

5 results

Serum oxytocin levels in patients with depression and the effects of gender and antidepressant treatment.

Ozsoy S, Esel E, Kula M

Psychiatry research3 Sept 2009Cited by 121 (Europe PMC)

PMID19732960 (opens in a new tab)DOI10.1016/j.psychres.2008.06.034 (opens in a new tab)PepBankPUB-19732960
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelNon-randomized trialOther

    In inpatients with depression, antidepressant drug treatment or ECT did not change serum oxytocin levels.

    In plain wordsIn people with depression, antidepressant drugs or ECT did not change the body's own oxytocin levels in blood.

    Peptide
    Oxytocin
    Outcome
    No significant changeSerum oxytocin after antidepressant drugs or ECT
    Study

    n = 40

    Comparator
    Pre-treatment level
    Outcome group
    Anxiety and mood · Mental health and mood

    Source sentences

    Summary
    Serum oxytocin levels were not affected by antidepressant drug treatment or ECT.
    1 context sentence
    Summary · context
    Serum oxytocin levels were measured before and after treatment with antidepressant drugs or electroconvulsive therapy (ECT) in 40 inpatients (30 women, 10 men) who met the DSM-IV criteria for major depressive disorder (n=29) or bipolar affective disorder depressive episode (n=11), and in 32 healthy…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In inpatients with depression, serum oxytocin levels were lower than in healthy controls, both before and after treatment.

    In plain wordsIn people with depression, the body's own oxytocin levels in blood were lower than in healthy controls, before and after treatment.

    Peptide
    Oxytocin
    Outcome
    DecreaseSerum oxytocin in depression versus controls
    Study

    n = 72

    Comparator
    Healthy controls
    Outcome group
    Anxiety and mood · Mental health and mood

    Source sentences

    Summary
    Serum oxytocin levels were decreased both pre-treatment and post-treatment in the patients compared with those in the controls.
    1 context sentence
    Summary · context
    Serum oxytocin levels were measured before and after treatment with antidepressant drugs or electroconvulsive therapy (ECT) in 40 inpatients (30 women, 10 men) who met the DSM-IV criteria for major depressive disorder (n=29) or bipolar affective disorder depressive episode (n=11), and in 32 healthy…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    Female patients with depression had significantly lower serum oxytocin levels than control females.

    In plain wordsWomen with depression had lower natural oxytocin levels in blood than healthy women.

    Peptide
    Oxytocin
    Outcome
    DecreaseSerum oxytocin in female patients versus control females
    Study

    n = 50

    Comparator
    Healthy control women
    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    The female patients had significantly lower oxytocin levels than the control females
    1 context sentence
    Summary · context
    Serum oxytocin levels were measured before and after treatment with antidepressant drugs or electroconvulsive therapy (ECT) in 40 inpatients (30 women, 10 men) who met the DSM-IV criteria for major depressive disorder (n=29) or bipolar affective disorder depressive episode (n=11), and in 32 healthy…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    Serum oxytocin levels did not differ between unipolar and bipolar depressive patients.

    In plain wordsThe body's own oxytocin levels in blood did not differ between people with unipolar and bipolar depression.

    Peptide
    Oxytocin
    Outcome
    No significant changeSerum oxytocin in unipolar versus bipolar depression
    Study

    n = 40

    Comparator
    Bipolar depressive patients
    Outcome group
    Anxiety and mood · Mental health and mood

    Source sentences

    Summary
    We found no difference in serum levels of oxytocin between the unipolar and bipolar depressive patients.
    1 context sentence
    Summary · context
    Serum oxytocin levels were measured before and after treatment with antidepressant drugs or electroconvulsive therapy (ECT) in 40 inpatients (30 women, 10 men) who met the DSM-IV criteria for major depressive disorder (n=29) or bipolar affective disorder depressive episode (n=11), and in 32 healthy…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelObservational studyOther

    Male patients with depression did not differ from male controls in serum oxytocin levels.

    In plain wordsMen with depression did not differ from healthy men in the body's own oxytocin levels in blood.

    Peptide
    Oxytocin
    Outcome
    No significant changeSerum oxytocin in male patients versus control males
    Study

    n = 22

    Comparator
    Healthy control men
    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    whereas no difference was found between the male patients and the male controls.
    1 context sentence
    Summary · context
    Serum oxytocin levels were measured before and after treatment with antidepressant drugs or electroconvulsive therapy (ECT) in 40 inpatients (30 women, 10 men) who met the DSM-IV criteria for major depressive disorder (n=29) or bipolar affective disorder depressive episode (n=11), and in 32 healthy…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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