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Study · Measured the body's own peptide · 2010

2 results

Androgen-mediated improvement of body composition and muscle function involves a novel early transcriptional program including IGF1, mechano growth factor, and induction of {beta}-catenin.

Gentile MA, Nantermet PV, Vogel RL, Phillips R, Holder D, Hodor P, Cheng C, Dai H, Freedman LP, Ray WJ

Journal of molecular endocrinology2 Sept 2009Cited by 56 (Europe PMC)

PMID19726620 (opens in a new tab)DOI10.1677/jme-09-0048 (opens in a new tab)PepBankPUB-19726620
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In aged castrated rats, dihydrotestosterone induced expression of IGF1 and its splice variant MGF in soleus muscle during the first week.

    In plain wordsIn aged castrated rats, dihydrotestosterone raised the body's own MGF in soleus muscle during the first week.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseSoleus muscle MGF expression after dihydrotestosterone
    Study

    ratn: not reported in source

    Aged castrated rats
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    During the first week, DHT transiently increased soleus muscle nuclear density and induced expression of IGF1 and its splice variant mechano growth factor (MGF) without early regulation of the myogenic factors MyoD, myogenin, monocyte nuclear factor, or myostatin.
    1 context sentence
    Summary · context
    Here, we demonstrate that aged castrated rats develop increased fat mass, reduced muscle mass and strength, and lower bone mass.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

  1. 02LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism

    In C2C12 myoblasts, treatment with both IGF1Ea and the MGF C-terminal peptide increased nuclear beta-catenin.

    In plain wordsIn cells, a mix of IGF1Ea and an MGF fragment raised beta-catenin in the nucleus of muscle precursor cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseNuclear beta-catenin after IGF1Ea and MGF C-terminal peptide
    Study

    mousen: not reported in source

    C2C12 myoblasts
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    Likewise, treatment of C2C12 myoblasts with both IGF1Ea and MGF C-terminal peptide increased nuclear beta-catenin in vitro.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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