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Study · Measured the body's own peptide · 2009

4 results

Cyclic force upregulates mechano-growth factor and elevates cell proliferation in 3D cultured skeletal myoblasts.

Li Y, Zhao Z, Song J, Feng Y, Wang Y, Li X, Liu Y, Yang P

Archives of biochemistry and biophysics29 Aug 2009Cited by 22 (Europe PMC)

PMID19720043 (opens in a new tab)DOI10.1016/j.abb.2009.08.016 (opens in a new tab)PepBankPUB-19720043
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Mechanism

    In 3D and 2D cultured rat myoblasts, mechanical stimulation increased MGF expression together with a rise in the cell proliferative index.

    In plain wordsIn rat muscle cells in the lab, stretching raised the cells' own MGF together with cell growth.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF expression after cyclic tensile strain
    Study

    ratn: not reported in source

    3D cultured rat skeletal myoblasts
    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal

    Source sentences

    Summary
    mechanical stimulation induced MGF upregulation commensurate with cell PI elevation both in the 3D and 2D cultured myoblasts
    1 context sentence
    Summary · context
    In this study, using a newly established system, we three-dimensionally (3D) cultured rat skeletal myoblasts and loaded them with cyclic uniaxial tensile strain of different magnitudes or time duration.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Mechanism

    In rat myoblasts, stronger mechanical force was needed to activate MGF expression in 3D cultures than in 2D cultures.

    In plain wordsIn rat muscle cells in the lab, 3D cultures needed stronger stretching than flat cultures to raise their own MGF.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableForce needed to activate MGF in 3D versus 2D cultures
    Study

    ratn: not reported in source

    3D cultured rat skeletal myoblasts
    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal

    Source sentences

    Summary
    mechanical stimulation induced MGF upregulation commensurate with cell PI elevation both in the 3D and 2D cultured myoblasts, but stronger mechanical force was needed to activate MGF expression in the 3D cultures
    1 context sentence
    Summary · context
    In this study, using a newly established system, we three-dimensionally (3D) cultured rat skeletal myoblasts and loaded them with cyclic uniaxial tensile strain of different magnitudes or time duration.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelIn vitro (cells)Mechanism

    In rat myoblasts, MGF but not IGF-IEa was essential for mechano-induced replication, because IGF-IEa upregulation lagged the rise in the proliferative index.

    In plain wordsIn rat muscle cells in the lab, the cells' own MGF, not IGF-IEa, was linked to stretch-driven cell growth.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableMGF versus IGF-IEa expression in relation to mechano-induced myoblast replication
    Study

    ratn: not reported in source

    3D cultured rat skeletal myoblasts
    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal

    Source sentences

    Summary
    MGF but not IGF-IEa was essential for mechano-induced myoblast replication, as IGF-IEa upregulation lagged cell PI elevation
    1 context sentence
    Summary · context
    After that, the cell proliferative index (PI) and mRNA expression of MGF, IGF-IEa and integrin beta1 were assayed.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  4. 04LabEndogenous levelIn vitro (cells)Mechanism

    In rat myoblasts, the time course of MGF and integrin beta1 upregulation was correlated, which suggests a shared mechanotransduction pathway.

    In plain wordsIn rat muscle cells in the lab, the cells' own MGF and integrin beta1 rose on a similar time course after stretching.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableTime course of MGF and integrin beta1 upregulation
    Study

    ratn: not reported in source

    3D cultured rat skeletal myoblasts
    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal

    Source sentences

    Summary
    the time course upregulation of MGF and integrin beta1 was correlated with each other, suggesting they shared a common mechanotransduction pathway
    1 context sentence
    Summary · context
    After that, the cell proliferative index (PI) and mRNA expression of MGF, IGF-IEa and integrin beta1 were assayed.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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