Skip to content

Study · Not a test of the peptide alone · 2009

2 results

A quantitative enterohepatic circulation model: development and evaluation with tesofensine and meloxicam.

Lehr T, Staab A, Tillmann C, Trommeshauser D, Schaefer HG, Kloft C

Clinical pharmacokinetics1 Jan 2009Cited by 28 (Europe PMC)

PMID19705923 (opens in a new tab)DOI10.2165/11313370-000000000-00000 (opens in a new tab)PepBankPUB-19705923
Publisher pagePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Tesofensine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Tesofensine.

  1. 01Computer modelNot a test of Tesofensine aloneIn silicoPharmacokinetics

    A three-compartment model with first-order elimination best described tesofensine concentration-time profiles.

    In plain wordsComputer analysis described tesofensine concentrations with a three-compartment model.

    Peptide
    Tesofensine
    Outcome
    Not applicableConcentration-time model
    Study

    n: not reported in source

    Enterohepatic circulation model
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Plasma concentration-time profiles of tesofensine were best described by a three-compartment model (absorption, central and gallbladder) with first-order elimination.
    2 context sentences
    Summary · context
    The EHC model was developed based on data from the tesofensine study, where EHC is suspected.
    Summary · context
    Modelling and simulation analyses were performed using the software programs NONMEM, SAS and Berkeley Madonna.

    In this study, Tesofensine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Tesofensine.

  2. 02Computer modelNot a test of Tesofensine aloneIn silicoPharmacokinetics

    The tesofensine model used a clock-time sine function to control periodic bile compartment release.

    In plain wordsComputer analysis used a periodic function to describe bile release in the tesofensine model.

    Peptide
    Tesofensine
    Outcome
    Not applicableBile compartment release model
    Study

    n: not reported in source

    Enterohepatic circulation model
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    The release of the bile compartment was controlled by a sine function model, switching the bile compartment periodically on and off using the actual clock time as the control element.
    2 context sentences
    Summary · context
    The EHC model was developed based on data from the tesofensine study, where EHC is suspected.
    Summary · context
    Modelling and simulation analyses were performed using the software programs NONMEM, SAS and Berkeley Madonna.

    In this study, Tesofensine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Tesofensine.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.