In neonatal rats with hypoxia-induced seizures, a single NAP injection dose-dependently prevented oxidative DNA damage.
In plain wordsIn rats with hypoxia-induced seizures, NAP prevented oxidative DNA damage compared with vehicle, with dose-dependent protection.
- Peptide
- Davunetide
- Outcome
- DecreaseDNA oxidative damage
- Study
Ratn: not reported in source
Neonatal hypoxia-induced seizures- Comparator
- Vehicle after hypoxia-induced seizures
- Outcome group
- Neuroprotection · Nervous system and cognition
- Studied dose
- 0.03, 0.3 or 3 microg/g · intraperitoneal · Single injectionAs given in this study (Rat).
Source sentences
a single NAP injection dose-dependently prevents HS-induced oxidative damage to DNA and lipid membranes, in correlation with modulation of the glutathione system.
2 context sentences(design, population, supporting numbers)
To evaluate its neuroprotective role in the context of seizures associated with perinatal hypoxia, we assessed the integrity of DNA and lipid membranes as well as the redox status in the hippocampus of 10-day-old rats exposed to hypoxia-induced seizures (HS) with and without NAP treatment.
Rats were exposed to transient global hypoxia (12 min exposure to 5-7% O2 was able to induce electrographic seizures) or room air with subsequent intraperitoneal NAP (0.03, 0.3 or 3 microg/g) or vehicle administration.