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Study · In vitro (cells) · mouse · 2009

8 results

Growth hormone-releasing peptide-2 stimulates secretion and synthesis of adrenocorticotropic hormone in mouse pituitary.

Kageyama K, Kushibiki M, Hanada K, Sakihara S, Yasujima M, Suda T

Regulatory peptides12 Aug 2009Cited by 3 (Europe PMC)

PMID19682503 (opens in a new tab)DOI10.1016/j.regpep.2009.07.018 (opens in a new tab)PepBankPUB-19682503
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In mouse anterior pituitary cells, GHRP‑2 directly stimulated ACTH secretion.

    In plain wordsIn mouse pituitary cells, GHRP‑2 directly increased ACTH release.

    Peptide
    GHRP-2
    Outcome
    IncreaseACTH secretion
    Study

    mousen: not reported in source

    mouse pituitary cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHRP-2 directly stimulated secretion and synthesis of ACTH in the mouse anterior pituitary cells.
    1 context sentence
    Summary · context
    In the present study, in order to elucidate the mechanism underlying ACTH secretion by GHRPs, mouse pituitary cells were stimulated by GHRP-2.
  2. 02LabIn vitro (cells)Efficacy outcome

    In mouse anterior pituitary cells, GHRP‑2 directly stimulated ACTH synthesis.

    In plain wordsIn mouse pituitary cells, GHRP‑2 directly increased ACTH production.

    Peptide
    GHRP-2
    Outcome
    IncreaseACTH synthesis
    Study

    mousen: not reported in source

    mouse pituitary cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHRP-2 directly stimulated secretion and synthesis of ACTH in the mouse anterior pituitary cells.
    1 context sentence
    Summary · context
    In the present study, in order to elucidate the mechanism underlying ACTH secretion by GHRPs, mouse pituitary cells were stimulated by GHRP-2.
  3. 03LabIn vitro (cells)Mechanism

    In mouse pituitary cells, GHRP‑2 increased intracellular cyclic AMP production.

    In plain wordsIn mouse pituitary cells, GHRP‑2 raised an internal signalling molecule called cyclic AMP.

    Peptide
    GHRP-2
    Outcome
    IncreaseIntracellular cyclic AMP production
    Study

    mousen: not reported in source

    mouse pituitary cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHRP-2 increased intracellular cyclic AMP production.
    1 context sentence
    Summary · context
    In the present study, in order to elucidate the mechanism underlying ACTH secretion by GHRPs, mouse pituitary cells were stimulated by GHRP-2.

Studies that did not test the peptide alone5

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

  1. 04LabNot a test of GHRP-2 aloneIn vitro (cells)Mechanism

    In mouse pituitary cells, the PKA inhibitor H89 inhibited GHRP‑2-induced ACTH release.

    In plain wordsIn mouse pituitary cells, a PKA blocker called H89 reduced the ACTH release that GHRP‑2 caused.

    Peptide
    GHRP-2
    Outcome
    DecreaseGHRP-2-induced ACTH release with H89 (PKA inhibitor)
    Study

    mousen: not reported in source

    mouse pituitary cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    H89, a potent protein kinase A (PKA) inhibitor, and bisindolylmaleimide I, a selective protein kinase C (PKC) inhibitor, inhibited the GHRP-2-induced ACTH release
    1 context sentence
    Summary · context
    In the present study, in order to elucidate the mechanism underlying ACTH secretion by GHRPs, mouse pituitary cells were stimulated by GHRP-2.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  2. 05LabNot a test of GHRP-2 aloneIn vitro (cells)Mechanism

    In mouse pituitary cells, the PKC inhibitor bisindolylmaleimide I inhibited GHRP‑2-induced ACTH release.

    In plain wordsIn mouse pituitary cells, a PKC blocker called bisindolylmaleimide I reduced the ACTH release that GHRP‑2 caused.

    Peptide
    GHRP-2
    Outcome
    DecreaseGHRP-2-induced ACTH release with bisindolylmaleimide I (PKC inhibitor)
    Study

    mousen: not reported in source

    mouse pituitary cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    H89, a potent protein kinase A (PKA) inhibitor, and bisindolylmaleimide I, a selective protein kinase C (PKC) inhibitor, inhibited the GHRP-2-induced ACTH release
    1 context sentence
    Summary · context
    In the present study, in order to elucidate the mechanism underlying ACTH secretion by GHRPs, mouse pituitary cells were stimulated by GHRP-2.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  3. 06LabNot a test of GHRP-2 aloneIn vitro (cells)Mechanism

    In mouse pituitary cells, H89 inhibited the GHRP‑2-induced proopiomelanocortin mRNA levels.

    In plain wordsIn mouse pituitary cells, the PKA blocker H89 reduced the rise in POMC gene activity that GHRP‑2 caused.

    Peptide
    GHRP-2
    Outcome
    DecreaseGHRP-2-induced POMC mRNA with H89 (PKA inhibitor)
    Study

    mousen: not reported in source

    mouse pituitary cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    and that H89, but not bisindolylmaleimide I, inhibited the GHRP-2-induced proopiomelanocortin mRNA levels.
    1 context sentence
    Summary · context
    In the present study, in order to elucidate the mechanism underlying ACTH secretion by GHRPs, mouse pituitary cells were stimulated by GHRP-2.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  4. 07LabNot a test of GHRP-2 aloneIn vitro (cells)Mechanism

    In mouse pituitary cells, bisindolylmaleimide I did not inhibit the GHRP‑2-induced proopiomelanocortin mRNA levels.

    In plain wordsIn mouse pituitary cells, the PKC blocker bisindolylmaleimide I did not reduce the POMC gene activity that GHRP‑2 caused.

    Peptide
    GHRP-2
    Outcome
    No significant changeGHRP-2-induced POMC mRNA with bisindolylmaleimide I (PKC inhibitor)
    Study

    mousen: not reported in source

    mouse pituitary cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    and that H89, but not bisindolylmaleimide I, inhibited the GHRP-2-induced proopiomelanocortin mRNA levels.
    1 context sentence
    Summary · context
    In the present study, in order to elucidate the mechanism underlying ACTH secretion by GHRPs, mouse pituitary cells were stimulated by GHRP-2.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  5. 08LabNot a test of GHRP-2 aloneIn vitro (cells)Mechanism

    GHRP receptor mRNA was expressed in the mouse pituitary.

    In plain wordsIn mice, the receptor that GHRP‑2 acts on is present in the pituitary gland.

    Peptide
    GHRP-2
    Outcome
    Not applicableGHRP receptor mRNA expression in mouse pituitary
    Study

    mousen: not reported in source

    mouse pituitary cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    GHRP receptor mRNA was expressed in the mouse pituitary, and GHRP-2 directly stimulated secretion and synthesis of ACTH in the mouse anterior pituitary cells.
    1 context sentence
    Summary · context
    In the present study, in order to elucidate the mechanism underlying ACTH secretion by GHRPs, mouse pituitary cells were stimulated by GHRP-2.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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