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Study · Animal study (in vivo) · rat · 2010

7 results

Comparison of the temporary dynamics of NGF and BDNF gene expression in rat hippocampus, frontal cortex, and retina under Semax action.

Shadrina M, Kolomin T, Agapova T, Agniullin Y, Shram S, Slominsky P, Lymborska S, Myasoedov N

Journal of molecular neuroscience : MN7 Aug 2009Cited by 9 (Europe PMC)

PMID19662538 (opens in a new tab)DOI10.1007/s12031-009-9270-z (opens in a new tab)PepBankPUB-19662538
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, NGF gene expression in the hippocampus was decreased 20 min after Semax administration.

    In plain wordsIn rats, Semax lowered the activity of the NGF gene in the hippocampus after 20 minutes.

    Peptide
    Semax
    Outcome
    DecreaseNGF gene expression in hippocampus at 20 min
    Study

    ratn: not reported in source

    Male Wistar rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The expression of both neurotrophin genes was decreased in rat hippocampus and retina 20 min after Semax administration and was increased in the frontal cortex.
    2 context sentences
    Summary · context
    Male Wistar rats were treated for 20 min, 40 min, 90 min, 3 h, 8 h, and 24 h with Semax.
    Summary · context
    Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) gene expression in rat brain and retina was analyzed by real-time polymerase chain reaction.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, BDNF gene expression in the hippocampus was decreased 20 min after Semax administration.

    In plain wordsIn rats, Semax lowered the activity of the BDNF gene in the hippocampus after 20 minutes.

    Peptide
    Semax
    Outcome
    DecreaseBDNF gene expression in hippocampus at 20 min
    Study

    ratn: not reported in source

    Male Wistar rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The expression of both neurotrophin genes was decreased in rat hippocampus and retina 20 min after Semax administration and was increased in the frontal cortex.
    2 context sentences
    Summary · context
    Male Wistar rats were treated for 20 min, 40 min, 90 min, 3 h, 8 h, and 24 h with Semax.
    Summary · context
    Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) gene expression in rat brain and retina was analyzed by real-time polymerase chain reaction.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, the abstract gives conflicting reports for retinal NGF expression after Semax: decreased 20 min after administration in one sentence, and practically constant at the initial stage in another.

    In plain wordsIn rats, reports conflict on early retinal NGF activity after Semax: one says it fell at 20 minutes, another says it stayed almost constant.

    Peptide
    Semax
    Outcome
    MixedNGF gene expression in retina at 20 min
    Study

    ratn: not reported in source

    Male Wistar rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The expression of both neurotrophin genes was decreased in rat hippocampus and retina 20 min after Semax administration and was increased in the frontal cortex.
    3 context sentences
    Summary · context
    The expression levels of NGF remained practically constant in the retina at the initial stage, whereas the expression levels of BDNF were significantly increased 90 min after Semax administration.
    Summary · context
    Male Wistar rats were treated for 20 min, 40 min, 90 min, 3 h, 8 h, and 24 h with Semax.
    Summary · context
    Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) gene expression in rat brain and retina was analyzed by real-time polymerase chain reaction.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, BDNF gene expression in the retina was decreased 20 min after Semax administration.

    In plain wordsIn rats, Semax lowered the activity of the BDNF gene in the retina after 20 minutes.

    Peptide
    Semax
    Outcome
    DecreaseBDNF gene expression in retina at 20 min
    Study

    ratn: not reported in source

    Male Wistar rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The expression of both neurotrophin genes was decreased in rat hippocampus and retina 20 min after Semax administration and was increased in the frontal cortex.
    2 context sentences
    Summary · context
    Male Wistar rats were treated for 20 min, 40 min, 90 min, 3 h, 8 h, and 24 h with Semax.
    Summary · context
    Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) gene expression in rat brain and retina was analyzed by real-time polymerase chain reaction.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats, NGF gene expression in the frontal cortex was increased 20 min after Semax administration.

    In plain wordsIn rats, Semax raised the activity of the NGF gene in the frontal cortex after 20 minutes.

    Peptide
    Semax
    Outcome
    IncreaseNGF gene expression in frontal cortex at 20 min
    Study

    ratn: not reported in source

    Male Wistar rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The expression of both neurotrophin genes was decreased in rat hippocampus and retina 20 min after Semax administration and was increased in the frontal cortex.
    2 context sentences
    Summary · context
    Male Wistar rats were treated for 20 min, 40 min, 90 min, 3 h, 8 h, and 24 h with Semax.
    Summary · context
    Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) gene expression in rat brain and retina was analyzed by real-time polymerase chain reaction.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats, BDNF gene expression in the frontal cortex was increased 20 min after Semax administration.

    In plain wordsIn rats, Semax raised the activity of the BDNF gene in the frontal cortex after 20 minutes.

    Peptide
    Semax
    Outcome
    IncreaseBDNF gene expression in frontal cortex at 20 min
    Study

    ratn: not reported in source

    Male Wistar rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The expression of both neurotrophin genes was decreased in rat hippocampus and retina 20 min after Semax administration and was increased in the frontal cortex.
    2 context sentences
    Summary · context
    Male Wistar rats were treated for 20 min, 40 min, 90 min, 3 h, 8 h, and 24 h with Semax.
    Summary · context
    Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) gene expression in rat brain and retina was analyzed by real-time polymerase chain reaction.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats, BDNF expression levels in the retina were significantly increased 90 min after Semax administration.

    In plain wordsIn rats, Semax raised BDNF gene activity in the retina after 90 minutes.

    Peptide
    Semax
    Outcome
    IncreaseBDNF gene expression in retina at 90 min
    Study

    ratn: not reported in source

    Male Wistar rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    whereas the expression levels of BDNF were significantly increased 90 min after Semax administration.
    2 context sentences
    Summary · context
    Male Wistar rats were treated for 20 min, 40 min, 90 min, 3 h, 8 h, and 24 h with Semax.
    Summary · context
    Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) gene expression in rat brain and retina was analyzed by real-time polymerase chain reaction.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 10:21 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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