Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia.

Dmitrieva VG, Povarova OV, Skvortsova VI, Limborska SA, Myasoedov NF, Dergunova LV

Cellular and molecular neurobiology25 Jul 2009Cited by 30 (Europe PMC)

PMID19633950PMCIDPMC11498467DOI10.1007/s10571-009-9432-0PepBankPUB-19633950

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats 3 h after pMCAO, Semax enhanced transcription of Bdnf in the cortex.
In plain wordsIn rats with brain ischemia, Semax raised activity of the Bdnf gene 3 hours after the blockage.
Peptide
Semax
Outcome
IncreaseBdnf transcription 3 h after pMCAO
Study
ratn: not reported in source
Permanent middle cerebral artery occlusion (pMCAO), cortex
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Semax enhanced the transcription of Bdnf, TrkC, and TrkA 3 h after occlusion, Nt-3 and Ngf 24 h after occlusion, and Ngf 72 h after occlusion.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the mRNA expression of neurotrophins and their receptors after treatment with either Semax or PGP, the rat brains were analyzed at three time points following a permanent middle cerebral artery occlusion (pMCAO).
Report a problemFND-1963395001
02AnimalAnimal study (in vivo)Mechanism
In rats 3 h after pMCAO, Semax enhanced transcription of TrkC in the cortex.
In plain wordsIn rats with brain ischemia, Semax raised activity of the TrkC gene 3 hours after the blockage.
Peptide
Semax
Outcome
IncreaseTrkC transcription 3 h after pMCAO
Study
ratn: not reported in source
Permanent middle cerebral artery occlusion (pMCAO), cortex
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Semax enhanced the transcription of Bdnf, TrkC, and TrkA 3 h after occlusion, Nt-3 and Ngf 24 h after occlusion, and Ngf 72 h after occlusion.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the mRNA expression of neurotrophins and their receptors after treatment with either Semax or PGP, the rat brains were analyzed at three time points following a permanent middle cerebral artery occlusion (pMCAO).
Report a problemFND-1963395002
03AnimalAnimal study (in vivo)Mechanism
In rats 3 h after pMCAO, Semax enhanced transcription of TrkA in the cortex.
In plain wordsIn rats with brain ischemia, Semax raised activity of the TrkA gene 3 hours after the blockage.
Peptide
Semax
Outcome
IncreaseTrkA transcription 3 h after pMCAO
Study
ratn: not reported in source
Permanent middle cerebral artery occlusion (pMCAO), cortex
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Semax enhanced the transcription of Bdnf, TrkC, and TrkA 3 h after occlusion, Nt-3 and Ngf 24 h after occlusion, and Ngf 72 h after occlusion.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the mRNA expression of neurotrophins and their receptors after treatment with either Semax or PGP, the rat brains were analyzed at three time points following a permanent middle cerebral artery occlusion (pMCAO).
Report a problemFND-1963395003
04AnimalAnimal study (in vivo)Mechanism
In rats 24 h after pMCAO, Semax enhanced transcription of Nt-3 in the cortex.
In plain wordsIn rats with brain ischemia, Semax raised activity of the Nt-3 gene 24 hours after the blockage.
Peptide
Semax
Outcome
IncreaseNt-3 transcription 24 h after pMCAO
Study
ratn: not reported in source
Permanent middle cerebral artery occlusion (pMCAO), cortex
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Semax enhanced the transcription of Bdnf, TrkC, and TrkA 3 h after occlusion, Nt-3 and Ngf 24 h after occlusion, and Ngf 72 h after occlusion.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the mRNA expression of neurotrophins and their receptors after treatment with either Semax or PGP, the rat brains were analyzed at three time points following a permanent middle cerebral artery occlusion (pMCAO).
Report a problemFND-1963395004
05AnimalAnimal study (in vivo)Mechanism
In rats 24 h after pMCAO, Semax enhanced transcription of Ngf in the cortex.
In plain wordsIn rats with brain ischemia, Semax raised activity of the Ngf gene 24 hours after the blockage.
Peptide
Semax
Outcome
IncreaseNgf transcription 24 h after pMCAO
Study
ratn: not reported in source
Permanent middle cerebral artery occlusion (pMCAO), cortex
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Semax enhanced the transcription of Bdnf, TrkC, and TrkA 3 h after occlusion, Nt-3 and Ngf 24 h after occlusion, and Ngf 72 h after occlusion.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the mRNA expression of neurotrophins and their receptors after treatment with either Semax or PGP, the rat brains were analyzed at three time points following a permanent middle cerebral artery occlusion (pMCAO).
Report a problemFND-1963395005
06AnimalAnimal study (in vivo)Mechanism
In rats 72 h after pMCAO, Semax enhanced transcription of Ngf in the cortex.
In plain wordsIn rats with brain ischemia, Semax raised activity of the Ngf gene 72 hours after the blockage.
Peptide
Semax
Outcome
IncreaseNgf transcription 72 h after pMCAO
Study
ratn: not reported in source
Permanent middle cerebral artery occlusion (pMCAO), cortex
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Semax enhanced the transcription of Bdnf, TrkC, and TrkA 3 h after occlusion, Nt-3 and Ngf 24 h after occlusion, and Ngf 72 h after occlusion.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the mRNA expression of neurotrophins and their receptors after treatment with either Semax or PGP, the rat brains were analyzed at three time points following a permanent middle cerebral artery occlusion (pMCAO).
Report a problemFND-1963395006
07AnimalAnimal study (in vivo)Mechanism
In rat cortex, Semax selectively affected the transcription of neurotrophins and their receptors in ischemic rats, compared with rats without surgery and sham-operated rats.
In plain wordsIn rats, Semax changed neurotrophin gene activity mainly in the ischemic cortex, compared with rats without surgery or with sham surgery.
Peptide
Semax
Outcome
MixedSelectivity of neurotrophin transcription effects in ischemic cortex
Study
ratn: not reported in source
Permanent middle cerebral artery occlusion (pMCAO), cortex
Comparator
Rats without surgery and sham-operated rats
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
revealed that Semax selectively affected the transcription of neurotrophins and their receptors in the ischemic rat cortex
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the mRNA expression of neurotrophins and their receptors after treatment with either Semax or PGP, the rat brains were analyzed at three time points following a permanent middle cerebral artery occlusion (pMCAO).
Report a problemFND-1963395007

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 19:08 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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