In human skin equivalent cultures, the biomarker approach detected matrix effects in response to Pal-KTTKS without specifying their direction.
In plain wordsIn cells, Pal-KTTKS produced detectable matrix biomarker effects, but the abstract does not state their direction.
- Outcome
- Direction not reportedMatrix biomarker response
- Study
humann: not reported in source
Human skin equivalent cultures- Outcome group
- Skin and hair · Skin and wound
- Studied dose
- Dose not stated
Source sentences
Using this in vitro biomarker approach, it is possible to detect skin barrier enhancement in response to the compounds niacinamide and hexamidine, matrix effects to the peptides Pal-KT and Pal-KTTKS, and hydration and matrix responses to niacinamide and N-acetylglucosamine.
1 context sentence(design, population, supporting numbers)
Human skin equivalent cultures allow topical application of test compounds, combinations and products to their stratum corneum surface and measurement of predictive biomarkers.