In human plasmacytoid dendritic cells, activation by phosphodiester ODNs and genomic DNA required complexation with cationic molecules such as LL37 or a scrambled derivative.
In plain wordsIn cells, DNA activated immune cells only when bound to cationic molecules such as LL37, used here as a tool.
- Peptide
- LL-37
- Outcome
- Not applicableNeed for cationic complexation for DNA activation of PDC
- Study
humann: not reported in source
human plasmacytoid dendritic cells (PDC)- Outcome group
- Immune response · Immune and inflammation
Source sentences
For activation of PDC, phosphodiester ODNs and genomic DNA strictly required complexation with cationic molecules such as the keratinocyte-derived antimicrobial peptide LL37 or a scrambled derivative.
In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.