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Study · In vitro (cells) · 2009

2 results

NAP protects against cytochrome c release: inhibition of the initiation of apoptosis.

Zemlyak I, Sapolsky R, Gozes I

European journal of pharmacology18 Jul 2009Cited by 28 (Europe PMC)

PMID19619522 (opens in a new tab)DOI10.1016/j.ejphar.2009.07.013 (opens in a new tab)PepBankPUB-19619522
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cortical neurons under oxygen-glucose deprivation, NAP completely blocked cytochrome c release.

    In plain wordsIn cells deprived of oxygen and glucose, NAP completely blocked cytochrome c release.

    Peptide
    Davunetide
    Outcome
    DecreaseCytochrome c release
    Study

    n: not reported in source

    Cortical neurons under oxygen-glucose deprivation
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10(-14)M to 10(-8)MAs given in this study.

    Source sentences

    Summary
    Here, NAP in concentrations ranging from 10(-14)M to 10(-8)M completely blocked cytochrome c release in cortical neurons subjected to oxygen-glucose deprivation.
  2. 02LabIn vitro (cells)Mechanism

    In cultured neurons under oxidative stress, microscopy suggested that NAP prevented microtubule degradation.

    In plain wordsIn lab tests under oxidative stress, microscopy suggested that NAP prevented microtubule damage.

    Peptide
    Davunetide
    Outcome
    DecreaseMicrotubule degradation
    Study

    n: not reported in source

    Cultured neurons under oxidative stress
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, quantitative microscopy coupled to microtubule immunocytochemistry suggested that NAP prevented microtubule degradation under oxidative stress.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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