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Study · Animal study (in vivo) · rat · 2009

4 results

Modulary effects of oxytocin and carbetocin on stress-induced changes in rat behavior in the open-field.

Klenerova V, Krejci I, Sida P, Hlinak Z, Hynie S

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society1 Jun 2009Cited by 21 (Europe PMC)

PMID19617646 (opens in a new tab)PepBankPUB-19617646
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In stressed rats, oxytocin 0.3 mg/kg showed only a tendency to restore the suppressed open-field exploratory activity.

    In plain wordsIn stressed rats, a lower oxytocin dose showed only a tendency to restore reduced exploring.

    Peptide
    Oxytocin
    Outcome
    No significant changeExploratory activity in open-field after stress
    Study

    ratn: not reported in source

    Wistar male rats exposed to restraint stress
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    0.3 mg/kg · intraperitoneal · 3 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    OXY in 0.3 mg/kg dose showed a tendency to restore the suppressed exploratory activity.
    1 context sentence
    Summary · context
    Wistar male rats were exposed to restraint for 1 hour; saline or drugs were administered intraperitoneally immediately after stress termination.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In stressed rats, oxytocin 1 mg/kg potentiated the stress-induced behavioral deficit in the open-field.

    In plain wordsIn stressed rats, a higher oxytocin dose made the stress-related drop in behavior worse.

    Peptide
    Oxytocin
    Outcome
    DecreaseStress-induced behavioral deficit in open-field
    Study

    ratn: not reported in source

    Wistar male rats exposed to restraint stress
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    1 mg/kg · intraperitoneal · 3 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    In contrast, 1 mg/kg dose potentiated the stress-induced behavioral deficit.
    1 context sentence
    Summary · context
    Wistar male rats were exposed to restraint for 1 hour; saline or drugs were administered intraperitoneally immediately after stress termination.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, both oxytocin doses slightly increased grooming in the open-field.

    In plain wordsIn rats, both oxytocin doses slightly raised grooming.

    Peptide
    Oxytocin
    Outcome
    IncreaseGrooming in open-field
    Study

    ratn: not reported in source

    Wistar male rats exposed to restraint stress
    Outcome group
    Locomotor and behavioral activity · Mental health and mood
    Studied dose
    0.3 and 1 mg/kg · intraperitoneal · 3 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    Both OXY doses slightly increased grooming.
    1 context sentence
    Summary · context
    Wistar male rats were exposed to restraint for 1 hour; saline or drugs were administered intraperitoneally immediately after stress termination.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In non-stressed rats, oxytocin 1 mg/kg caused locomotor depression in the open-field.

    In plain wordsIn rats without stress, the higher oxytocin dose reduced movement.

    Peptide
    Oxytocin
    Outcome
    DecreaseLocomotor activity in non-stressed rats
    Study

    ratn: not reported in source

    Wistar male rats, non-stressed
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    1 mg/kg · intraperitoneal · 3 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    The locomotor depression after 1 mg dose of OXY was found also in non-stressed rats
    1 context sentence
    Summary · context
    Wistar male rats were exposed to restraint for 1 hour; saline or drugs were administered intraperitoneally immediately after stress termination.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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