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Study · Non-randomized trial · 2009

6 results

Intra-arterial AICA-riboside administration induces NO-dependent vasodilation in vivo in human skeletal muscle.

Bosselaar M, Boon H, van Loon LJ, van den Broek PH, Smits P, Tack CJ

American journal of physiology. Endocrinology and metabolism14 Jul 2009Cited by 10 (Europe PMC)

PMID19602584 (opens in a new tab)DOI10.1152/ajpendo.00141.2009 (opens in a new tab)PepBankPUB-19602584
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. 2 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In healthy subjects, AICA-riboside increased forearm blood flow dose dependently from 2.0 to a maximum of 13.2 ml x min(-1) x dl(-1).

    In plain wordsIn healthy people, AICA-riboside increased forearm blood flow compared with baseline, with larger responses at higher doses.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseForearm blood flow
    Study

    n: not reported in source

    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    four dosages up to 8 mg x min(-1) x dl(-1) · intra-arterialAs given in this study (human).

    Measurements

    Forearm blood flow
    2 ml x min(-1) x dl(-1)
    baseline
    Forearm blood flow
    13.2 ml x min(-1) x dl(-1)
    maximum

    Source sentences

    Summary
    AICA-riboside increased FBF dose dependently from 2.0 +/- 0.2 to 13.2 +/- 1.9 ml x min(-1) x dl(-1) maximally (P < 0.05 for all dosages).
    1 context sentence
    Summary · context
    AICA-riboside was infused intra-arterially in four different dosages up to 8 mg x min(-1) x dl(-1) in 24 healthy subjects.
  2. 02HumanNon-randomized trialEfficacy outcome

    In healthy subjects, forearm glucose uptake did not change despite high plasma AICA-riboside concentrations.

    In plain wordsIn healthy people, AICA-riboside did not change forearm glucose uptake from baseline despite high blood concentrations.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeForearm glucose uptake
    Study

    n: not reported in source

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    four dosages up to 8 mg x min(-1) x dl(-1) · intra-arterialAs given in this study (human).

    Source sentences

    Summary
    Despite high plasma AICA-riboside concentrations, forearm glucose uptake did not change.
    1 context sentence
    Summary · context
    AICA-riboside was infused intra-arterially in four different dosages up to 8 mg x min(-1) x dl(-1) in 24 healthy subjects.
  3. 03LabIn vitro (cells)Pharmacokinetics

    In erythrocyte experiments, the equilibrative nucleoside transporter rapidly transported AICA-riboside into cells.

    In plain wordsIn lab tests, red blood cells rapidly absorbed AICA-riboside through the equilibrative nucleoside transporter.

    Peptide
    AICAR (acadesine)
    Outcome
    Not applicableCellular uptake
    Study

    n: not reported in source

    erythrocytes
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro experiments showed rapid uptake of AICA-riboside by the equilibrative nucleoside transporter in erythrocytes and subsequent phosphorylation to AICA-ribotide.
  4. 04LabIn vitro (cells)Pharmacokinetics

    In erythrocyte experiments, intracellular AICA-riboside underwent phosphorylation to AICA-ribotide.

    In plain wordsIn lab tests, red blood cells converted absorbed AICA-riboside to AICA-ribotide through phosphorylation.

    Peptide
    AICAR (acadesine)
    Outcome
    Not applicablePhosphorylation to AICA-ribotide
    Study

    n: not reported in source

    erythrocytes
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro experiments showed rapid uptake of AICA-riboside by the equilibrative nucleoside transporter in erythrocytes and subsequent phosphorylation to AICA-ribotide.

Studies that did not test the peptide alone2

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 05HumanNot a test of AICAR (acadesine) aloneNon-randomized trialEfficacy outcome

    In healthy subjects, caffeine did not reduce AICA-riboside-induced forearm vasodilation.

    In plain wordsIn healthy people, caffeine did not reduce the blood-flow response compared with AICA-riboside alone.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeCaffeine effect on vasodilation
    Study

    n = 6

    Comparator
    AICA-riboside alone
    Outcome group
    Vascular function · Cardiovascular

    Source sentences

    Summary
    The latter was not reduced by caffeine administration but was significantly attenuated by l-NMMA infusion.
    2 context sentences
    Summary · context
    We also combined AICA-riboside infusion (2 mg x min(-1) x dl(-1)) with the intra-arterial administration of the adenosine receptor antagonist caffeine (90 microg x min(-1) x dl(-1); n = 6) and with the endothelial NO synthase inhibitor l-NMMA (0.4 mg x min(-1) x dl(-1); n = 6).
    Summary · context
    AICA-riboside was infused intra-arterially in four different dosages up to 8 mg x min(-1) x dl(-1) in 24 healthy subjects.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 06HumanNot a test of AICAR (acadesine) aloneNon-randomized trialEfficacy outcome

    In healthy subjects, l-NMMA significantly attenuated AICA-riboside-induced forearm vasodilation.

    In plain wordsIn healthy people, l-NMMA reduced the blood-flow response compared with AICA-riboside alone.

    Peptide
    AICAR (acadesine)
    Outcome
    Decreasel-NMMA effect on vasodilation
    Study

    n = 6

    Comparator
    AICA-riboside alone
    Outcome group
    Vascular function · Cardiovascular

    Source sentences

    Summary
    The latter was not reduced by caffeine administration but was significantly attenuated by l-NMMA infusion.
    2 context sentences
    Summary · context
    We also combined AICA-riboside infusion (2 mg x min(-1) x dl(-1)) with the intra-arterial administration of the adenosine receptor antagonist caffeine (90 microg x min(-1) x dl(-1); n = 6) and with the endothelial NO synthase inhibitor l-NMMA (0.4 mg x min(-1) x dl(-1); n = 6).
    Summary · context
    AICA-riboside was infused intra-arterially in four different dosages up to 8 mg x min(-1) x dl(-1) in 24 healthy subjects.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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