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Study · Not a test of the peptide alone · 2009

3 results

Energetics investigation on encapsulation of protein/peptide drugs in carbon nanotubes.

Chen Q, Wang Q, Liu YC, Wu T, Kang Y, Moore JD, Gubbins KE

The Journal of chemical physics1 Jul 2009Cited by 26 (Europe PMC)

PMID19586122 (opens in a new tab)DOI10.1063/1.3148025 (opens in a new tab)PepBankPUB-19586122
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 01Computer modelNot a test of Thymosin alpha-1 aloneIn silicoOther

    In molecular dynamics simulations, Zadaxin was encapsulated inside a carbon nanotube after spontaneous insertion and oscillated around the tube centre, where the van der Waals interaction energy was lowest.

    In plain wordsIn computer simulations, the peptide moved into a carbon nanotube by itself and stayed near its centre.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableEncapsulation of Zadaxin inside a carbon nanotube
    Study

    n: not reported in source

    molecular dynamics simulation of Zadaxin in carbon nanotubes
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    In the molecular dynamics (MD) simulations, the protein/peptide molecule Zadaxin is observed to be encapsulated inside the nanotube after its spontaneous insertion and oscillates around the center of the tube, where the van der Waals interaction energy is observed to be a minimum.
    1 context sentence
    Summary · context
    This work focuses on the dynamic properties and energetics of the protein/peptide drug during its transport through carbon nanotubes (CNTs).

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  2. 02Computer modelNot a test of Thymosin alpha-1 aloneIn silicoOther

    In steered molecular dynamics simulations, the pulling force on the peptide reached a maximum value, showing that carbon nanotubes can trap the peptide.

    In plain wordsIn computer simulations, carbon nanotubes held the peptide against a pulling force.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicablePulling force needed to remove Zadaxin from a carbon nanotube
    Study

    n: not reported in source

    molecular dynamics simulation of Zadaxin in carbon nanotubes
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    Furthermore, it is found by performing steered MD simulations that the pulling force applied to the peptide reaches a maximum value, which demonstrates the ability of the CNTs to trap protein/peptide drugs.
    1 context sentence
    Summary · context
    This work focuses on the dynamic properties and energetics of the protein/peptide drug during its transport through carbon nanotubes (CNTs).

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  3. 03Computer modelNot a test of Thymosin alpha-1 aloneIn silicoOther

    In simulations, longer nanotubes gave a broader area to trap the peptide, and smaller nanotubes encapsulated it with a deeper interaction energy well.

    In plain wordsIn computer simulations, longer tubes trapped the peptide over a wider area and narrower tubes held it more tightly.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableEffect of nanotube length and diameter on peptide trapping
    Study

    n: not reported in source

    molecular dynamics simulation of Zadaxin in carbon nanotubes
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    Longer nanotubes provide a broader area to trap the peptide, while smaller nanotubes are able to encapsulate the peptide with a deeper interaction energy well.
    1 context sentence
    Summary · context
    This work focuses on the dynamic properties and energetics of the protein/peptide drug during its transport through carbon nanotubes (CNTs).

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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