Establishment of reference values for endocrine tests. Part VII: growth hormone deficiency.

Eskes SA, Tomasoa NB, Endert E, Geskus RB, Fliers E, Wiersinga WM

The Netherlands journal of medicine1 Apr 2009Cited by 9 (Europe PMC)

PMID19581656PepBankPUB-19581656

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

01HumanNot a test of GHRP-6 aloneNon-randomized trialActivity measurement
In reference subjects, BMI significantly affected the GH response to the combined GHRH/GHRP‑6 test.
In plain wordsBMI affected growth hormone response to the combined GHRH/GHRP‑6 test. The abstract did not report the direction.
Peptide
GHRP-6
Outcome
Direction not reportedBMI association with stimulated GH response
Study
n = 49
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
whereas the GH response in the GHRH/GHRP-6 test was significantly affected by BMI
1 context sentence(design, population, supporting numbers)
Summary · context
Serum IGF-I level was measured in all subjects and an insulin tolerance test (0.15 U/kg Actrapid iv) and GHRH/GHRP-6 test (1 microg GHRH/kg and 1 microg GHRP-6/kg) were performed in 49 subjects.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1958165601
02HumanNot a test of GHRP-6 aloneNon-randomized trialActivity measurement
In reference subjects, GH response to the combined GHRH/GHRP‑6 test did not differ by sex.
In plain wordsGrowth hormone response to the combined GHRH/GHRP‑6 test did not differ between males and females.
Peptide
GHRP-6
Outcome
No significant changeSex difference in stimulated GH response
Study
n = 49
Comparator
Male versus female subjects
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
There was no sex difference in IGF-I and in the GHRH/GHRP-6 test, but in the ITT males had a higher GH peak.
1 context sentence(design, population, supporting numbers)
Summary · context
Serum IGF-I level was measured in all subjects and an insulin tolerance test (0.15 U/kg Actrapid iv) and GHRH/GHRP-6 test (1 microg GHRH/kg and 1 microg GHRP-6/kg) were performed in 49 subjects.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1958165602
03HumanNot a test of GHRP-6 aloneNon-randomized trialActivity measurement
In reference subjects, GH responses to the combined GHRH/GHRP‑6 test and ITT correlated significantly.
In plain wordsGrowth hormone responses to the combined GHRH/GHRP‑6 test and insulin tolerance test were linked.
Peptide
GHRP-6
Outcome
Direction not reportedCorrelation with ITT GH response
Study
n = 49
Comparator
Insulin tolerance test
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
There was a significant correlation between the GH responses in both tests
1 context sentence(design, population, supporting numbers)
Summary · context
Serum IGF-I level was measured in all subjects and an insulin tolerance test (0.15 U/kg Actrapid iv) and GHRH/GHRP-6 test (1 microg GHRH/kg and 1 microg GHRP-6/kg) were performed in 49 subjects.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1958165603
04HumanNot a test of GHRP-6 aloneNon-randomized trialActivity measurement
In reference subjects, GH response was higher with the combined GHRH/GHRP‑6 test than with ITT.
In plain wordsThe combined GHRH/GHRP‑6 test produced a higher growth hormone response than the insulin tolerance test.
Peptide
GHRP-6
Outcome
IncreaseStimulated GH response versus ITT
Study
n = 49
Comparator
Insulin tolerance test
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
and the GH response was significantly higher in the GHRH/GHRP-6 test than in the ITT.
1 context sentence(design, population, supporting numbers)
Summary · context
Serum IGF-I level was measured in all subjects and an insulin tolerance test (0.15 U/kg Actrapid iv) and GHRH/GHRP-6 test (1 microg GHRH/kg and 1 microg GHRP-6/kg) were performed in 49 subjects.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1958165604
05HumanNot a test of GHRP-6 aloneNon-randomized trialActivity measurement
The study established age-adjusted reference values for GH response to the combined GHRH/GHRP‑6 test.
In plain wordsThe study established age-adjusted growth hormone reference values for the combined GHRH/GHRP‑6 test.
Peptide
GHRP-6
Outcome
Not applicableAge-adjusted GH reference values
Study
n = 49
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Age-adjusted reference values were established for each test.
1 context sentence(design, population, supporting numbers)
Summary · context
Serum IGF-I level was measured in all subjects and an insulin tolerance test (0.15 U/kg Actrapid iv) and GHRH/GHRP-6 test (1 microg GHRH/kg and 1 microg GHRP-6/kg) were performed in 49 subjects.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1958165605

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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