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Study · Animal study (in vivo) · rat · 2009

5 results

Ghrelin receptor agonist, GHRP-2, attenuates burn injury-induced MuRF-1 and MAFbx expression and muscle proteolysis in rats.

Sheriff S, Joshi R, Friend LA, James JH, Balasubramaniam A

Peptides3 Jul 2009Cited by 19 (Europe PMC)

PMID19577604 (opens in a new tab)DOI10.1016/j.peptides.2009.06.029 (opens in a new tab)PepBankPUB-19577604
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats with thermal injury, 24 h GHRP‑2 release by minipump attenuated the burn-induced increase in IL-6 mRNA expression in skeletal muscle.

    In plain wordsIn rats with burns, GHRP‑2 reduced the burn-related rise in IL-6 gene activity in muscle.

    Peptide
    GHRP-2
    Outcome
    DecreaseIL-6 mRNA in skeletal muscle after burn
    Study

    ratn: not reported in source

    thermal injury (burn)
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · minipump (slow release) · 24 hAs given in this study (rat).

    Source sentences

    Summary
    Slow in vivo release of GHRP-2 through minipump for 24h attenuated the thermal injury-induced increase in mRNA expression of IL-6 and of the E3 ubiquitin ligases, MuRF-1 and MAFbx, in rat skeletal muscle.
    1 context sentence
    Summary · context
    Towards this goal, we examined the role of the hexapeptide mimetic of ghrelin, growth hormone-releasing peptide-2 (GHRP-2), on expression of E3 ubiquitin ligases and breakdown of muscle protein in rats with thermal injury.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with thermal injury, GHRP‑2 attenuated the burn-induced increase in MuRF-1 mRNA expression in skeletal muscle.

    In plain wordsIn rats with burns, GHRP‑2 reduced the burn-related rise in MuRF-1 gene activity in muscle.

    Peptide
    GHRP-2
    Outcome
    DecreaseMuRF-1 mRNA in skeletal muscle after burn
    Study

    ratn: not reported in source

    thermal injury (burn)
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated · minipump (slow release) · 24 hAs given in this study (rat).

    Source sentences

    Summary
    Slow in vivo release of GHRP-2 through minipump for 24h attenuated the thermal injury-induced increase in mRNA expression of IL-6 and of the E3 ubiquitin ligases, MuRF-1 and MAFbx, in rat skeletal muscle.
    1 context sentence
    Summary · context
    Towards this goal, we examined the role of the hexapeptide mimetic of ghrelin, growth hormone-releasing peptide-2 (GHRP-2), on expression of E3 ubiquitin ligases and breakdown of muscle protein in rats with thermal injury.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with thermal injury, GHRP‑2 attenuated the burn-induced increase in MAFbx mRNA expression in skeletal muscle.

    In plain wordsIn rats with burns, GHRP‑2 reduced the burn-related rise in MAFbx gene activity in muscle.

    Peptide
    GHRP-2
    Outcome
    DecreaseMAFbx mRNA in skeletal muscle after burn
    Study

    ratn: not reported in source

    thermal injury (burn)
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated · minipump (slow release) · 24 hAs given in this study (rat).

    Source sentences

    Summary
    Slow in vivo release of GHRP-2 through minipump for 24h attenuated the thermal injury-induced increase in mRNA expression of IL-6 and of the E3 ubiquitin ligases, MuRF-1 and MAFbx, in rat skeletal muscle.
    1 context sentence
    Summary · context
    Towards this goal, we examined the role of the hexapeptide mimetic of ghrelin, growth hormone-releasing peptide-2 (GHRP-2), on expression of E3 ubiquitin ligases and breakdown of muscle protein in rats with thermal injury.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with thermal injury, GHRP‑2 attenuated the burn-induced increase in total protein breakdown in EDL muscle.

    In plain wordsIn rats with burns, GHRP‑2 reduced the burn-related rise in total protein breakdown in a leg muscle.

    Peptide
    GHRP-2
    Outcome
    DecreaseTotal protein breakdown in EDL muscle after burn
    Study

    ratn: not reported in source

    thermal injury (burn)
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated · minipump (slow release) · 24 hAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, burn-induced increases in total and myofibrillar protein breakdown from rat EDL muscle were attenuated by GHRP-2.
    1 context sentence
    Summary · context
    Towards this goal, we examined the role of the hexapeptide mimetic of ghrelin, growth hormone-releasing peptide-2 (GHRP-2), on expression of E3 ubiquitin ligases and breakdown of muscle protein in rats with thermal injury.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with thermal injury, GHRP‑2 attenuated the burn-induced increase in myofibrillar protein breakdown in EDL muscle.

    In plain wordsIn rats with burns, GHRP‑2 reduced the burn-related rise in muscle fibre protein breakdown in a leg muscle.

    Peptide
    GHRP-2
    Outcome
    DecreaseMyofibrillar protein breakdown in EDL muscle after burn
    Study

    ratn: not reported in source

    thermal injury (burn)
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated · minipump (slow release) · 24 hAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, burn-induced increases in total and myofibrillar protein breakdown from rat EDL muscle were attenuated by GHRP-2.
    1 context sentence
    Summary · context
    Towards this goal, we examined the role of the hexapeptide mimetic of ghrelin, growth hormone-releasing peptide-2 (GHRP-2), on expression of E3 ubiquitin ligases and breakdown of muscle protein in rats with thermal injury.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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