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Study · Measured the body's own peptide · 2009

3 results

Cerebrospinal fluid oxytocin, life history of aggression, and personality disorder.

Lee R, Ferris C, Van de Kar LD, Coccaro EF

Psychoneuroendocrinology3 Jul 2009Cited by 88 (Europe PMC)

PMID19577376 (opens in a new tab)DOI10.1016/j.psyneuen.2009.06.002 (opens in a new tab)PepBankPUB-19577376
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyMechanism

    In people with and without personality disorders, the body's own cerebrospinal fluid oxytocin level was inversely correlated with life history of aggression.

    In plain wordsIn adults with and without personality disorders, lower natural oxytocin levels in spinal fluid were linked to more past aggression.

    Peptide
    Oxytocin
    Outcome
    DecreaseCSF oxytocin and life history of aggression
    Study

    n = 58

    Analysis
    Primary
    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    The model predicting variance in CSF Oxytocin concentration including LHA score was statistically significant, after removal of a single multivariate outlier.
    2 context sentences
    Summary · context
    As hypothesized, CSF Oxytocin levels were inversely correlated with life history of aggression.
    Summary · context
    Lumbar CSF for morning basal levels of oxytocin was obtained from 58 consenting subjects with and without DSM-IV personality disorders.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyMechanism

    In people with and without personality disorders, the presence of a personality disorder was not associated with variance in the body's own cerebrospinal fluid oxytocin levels.

    In plain wordsIn adults, natural oxytocin levels in spinal fluid did not differ with the presence of a personality disorder.

    Peptide
    Oxytocin
    Outcome
    No significant changeCSF oxytocin and presence of personality disorder
    Study

    n = 58

    Analysis
    Primary
    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    Presence or absence of personality disorder was not associated with variance in CSF Oxytocin levels.
    1 context sentence
    Summary · context
    Lumbar CSF for morning basal levels of oxytocin was obtained from 58 consenting subjects with and without DSM-IV personality disorders.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyMechanism

    In exploratory analyses, the body's own cerebrospinal fluid oxytocin level showed a possible inverse relationship with history of suicidal behavior.

    In plain wordsIn adults, lower natural oxytocin levels in spinal fluid were possibly linked to a history of suicidal behavior.

    Peptide
    Oxytocin
    Outcome
    DecreaseCSF oxytocin and history of suicidal behavior
    Study

    n = 58

    Analysis
    Exploratory
    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    Exploratory analyses revealed a possible inverse relationship between CSF Oxytocin level and history of suicidal behavior.
    1 context sentence
    Summary · context
    Lumbar CSF for morning basal levels of oxytocin was obtained from 58 consenting subjects with and without DSM-IV personality disorders.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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