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Study · Measured the body's own peptide · 2010

3 results

Investigation of MGF mRNA expression in patients with amyotrophic lateral sclerosis using parallel in vivo and in vitro approaches.

Evans RM, Harridge SD, Velloso CP, Yang SY, Goldspink G, Orrell RW

Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases1 Jan 2010Cited by 3 (Europe PMC)

PMID19572220 (opens in a new tab)DOI10.3109/17482960903089775 (opens in a new tab)PepBankPUB-19572220
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyMechanism

    In patients with ALS, baseline MGF mRNA in muscle biopsies was similar to that of healthy controls.

    In plain wordsIn people with ALS, the body's own MGF level in muscle at baseline was similar to that of healthy people.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeBaseline MGF mRNA in muscle, ALS patients versus healthy controls
    Study

    n: not reported in source

    Comparator
    Healthy controls
    Outcome group
    Muscle injury and repair · Nervous system and cognition

    Source sentences

    Summary
    Patients with ALS had similar baseline levels of MGF and IGF-IEa mRNA to healthy controls
    1 context sentence
    Summary · context
    We assessed the levels of MGF and IGF-IEa mRNA in muscle biopsy samples from healthy subjects and patients with ALS, before and after exercise.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyMechanism

    No up-regulation of muscle MGF mRNA was seen in patients with ALS or healthy controls shortly after a single bout of low intensity exercise.

    In plain wordsIn people with and without ALS, the body's own MGF level in muscle did not rise shortly after one light exercise bout.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeMGF mRNA after a single bout of low intensity exercise
    Study

    n: not reported in source

    Comparator
    Pre-exercise
    Outcome group
    Muscle injury and repair · Nervous system and cognition

    Source sentences

    Summary
    No up-regulation was seen in either group within a short time of a single bout of low intensity exercise.
    1 context sentence
    Summary · context
    We assessed the levels of MGF and IGF-IEa mRNA in muscle biopsy samples from healthy subjects and patients with ALS, before and after exercise.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelIn vitro (cells)Mechanism

    Three-dimensional human muscle constructs from control subjects or patients with ALS showed no MGF response to a mechanical stretch.

    In plain wordsIn lab tests, lab-grown muscle tissue from healthy donors and ALS donors showed no change in its own MGF after stretching.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeMGF response of 3D muscle constructs to mechanical stretch
    Study

    humann: not reported in source

    Three-dimensional collagen constructs of primary muscle cells
    Comparator
    Unstretched
    Outcome group
    Muscle injury and repair · Nervous system and cognition

    Source sentences

    Summary
    Three-dimensional human muscle constructs also detected no response to a mechanical stretch from either control subjects or ALS.
    1 context sentence
    Summary · context
    We used primary muscle cells to build three-dimensional collagen constructs and subjected them to a ramp stretch.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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