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Study · Animal study (in vivo) · rat · 2009

4 results

Role of gamma melanocyte-stimulating hormone-renal melanocortin 3 receptor system in blood pressure regulation in salt-resistant and salt-sensitive rats.

Chandramohan G, Durham N, Sinha S, Norris K, Vaziri ND

Metabolism: clinical and experimental1 Jul 2009Cited by 16 (Europe PMC)

PMID19570553 (opens in a new tab)DOI10.1016/j.metabol.2009.04.022 (opens in a new tab)PepBankPUB-19570553
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Dahl salt-resistant rats on a high-salt diet, melanotan II significantly lowered blood pressure.

    In plain wordsIn salt-resistant rats on a high-salt diet, melanotan II lowered blood pressure.

    Peptide
    Melanotan II
    Outcome
    DecreaseBlood pressure in DSR rats
    Study

    ratn: not reported in source

    in vivo, Dahl salt-resistant (DSR) and salt-sensitive (DSS) rats on high-salt diet
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Administration of MC3-R agonist melanotan II significantly lowered BP and raised fractional Na excretion in the DSR but not the DSS rats consuming high-salt diet
    1 context sentence
    Summary · context
    We examined renal MC3-R expression, plasma gammaMSH concentration, and response to MC3-R agonist and antagonist in Dahl salt-sensitive (DSS) and Dahl salt-resistant (DSR) rats fed high-salt (8%) or low-salt (0.07%) diets for 3 weeks.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In Dahl salt-resistant rats on a high-salt diet, melanotan II raised fractional sodium excretion.

    In plain wordsIn salt-resistant rats on a high-salt diet, melanotan II increased the amount of sodium passed in urine.

    Peptide
    Melanotan II
    Outcome
    IncreaseFractional sodium excretion in DSR rats
    Study

    ratn: not reported in source

    in vivo, Dahl salt-resistant (DSR) and salt-sensitive (DSS) rats on high-salt diet
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Administration of MC3-R agonist melanotan II significantly lowered BP and raised fractional Na excretion in the DSR but not the DSS rats consuming high-salt diet.
    1 context sentence
    Summary · context
    We examined renal MC3-R expression, plasma gammaMSH concentration, and response to MC3-R agonist and antagonist in Dahl salt-sensitive (DSS) and Dahl salt-resistant (DSR) rats fed high-salt (8%) or low-salt (0.07%) diets for 3 weeks.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In Dahl salt-sensitive rats on a high-salt diet, melanotan II did not significantly change blood pressure.

    In plain wordsIn salt-sensitive rats on a high-salt diet, melanotan II did not change blood pressure.

    Peptide
    Melanotan II
    Outcome
    No significant changeBlood pressure in DSS rats
    Study

    ratn: not reported in source

    in vivo, Dahl salt-resistant (DSR) and salt-sensitive (DSS) rats on high-salt diet
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Administration of MC3-R agonist melanotan II significantly lowered BP and raised fractional Na excretion in the DSR but not the DSS rats consuming high-salt diet.
    1 context sentence
    Summary · context
    We examined renal MC3-R expression, plasma gammaMSH concentration, and response to MC3-R agonist and antagonist in Dahl salt-sensitive (DSS) and Dahl salt-resistant (DSR) rats fed high-salt (8%) or low-salt (0.07%) diets for 3 weeks.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In Dahl salt-sensitive rats on a high-salt diet, melanotan II did not significantly change fractional sodium excretion.

    In plain wordsIn salt-sensitive rats on a high-salt diet, melanotan II did not change sodium passed in urine.

    Peptide
    Melanotan II
    Outcome
    No significant changeFractional sodium excretion in DSS rats
    Study

    ratn: not reported in source

    in vivo, Dahl salt-resistant (DSR) and salt-sensitive (DSS) rats on high-salt diet
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Administration of MC3-R agonist melanotan II significantly lowered BP and raised fractional Na excretion in the DSR but not the DSS rats consuming high-salt diet.
    1 context sentence
    Summary · context
    We examined renal MC3-R expression, plasma gammaMSH concentration, and response to MC3-R agonist and antagonist in Dahl salt-sensitive (DSS) and Dahl salt-resistant (DSR) rats fed high-salt (8%) or low-salt (0.07%) diets for 3 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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