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Study · Measured the body's own peptide · 2009

2 results

Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration.

Dumont GJ, Sweep FC, van der Steen R, Hermsen R, Donders AR, Touw DJ, van Gerven JM, Buitelaar JK, Verkes RJ

Social neuroscience1 Jan 2009Cited by 178 (Europe PMC)

PMID19562632 (opens in a new tab)DOI10.1080/17470910802649470 (opens in a new tab)PepBankPUB-19562632
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelRandomized controlled trialMechanism

    In healthy volunteers, oral MDMA 100 mg increased the body's own blood oxytocin concentrations versus placebo.

    In plain wordsIn healthy volunteers, the drug MDMA raised the body's own blood oxytocin levels compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseBlood oxytocin concentration after MDMA
    Study

    n = 15

    Comparator
    Placebo
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    MDMA induced a robust increase of blood oxytocin concentrations and an increase of subjective prosocial feelings.
    1 context sentence
    Summary · context
    In a double blind, randomized, crossover, and placebo-controlled study in 15 healthy volunteers we assessed blood oxytocin and MDMA concentrations and subjective prosocial effects after oral administration of 100 mg MDMA or placebo.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelRandomized controlled trialMechanism

    In healthy volunteers given MDMA, within-subject variation in prosocial feelings was positively correlated with variation in the body's own blood oxytocin, more strongly than with blood MDMA levels.

    In plain wordsIn healthy volunteers given MDMA, changes in prosocial feelings were linked to changes in the body's own oxytocin, more than to MDMA blood levels.

    Peptide
    Oxytocin
    Outcome
    Not applicableCorrelation of prosocial feelings with blood oxytocin
    Study

    n = 15

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Within subjects, the variations in these feelings were significantly and positively correlated with variation in oxytocin levels, and the correlations between these feelings and oxytocin were significantly stronger than those between these feelings and blood MDMA levels.
    1 context sentence
    Summary · context
    In a double blind, randomized, crossover, and placebo-controlled study in 15 healthy volunteers we assessed blood oxytocin and MDMA concentrations and subjective prosocial effects after oral administration of 100 mg MDMA or placebo.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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