Noopept reduces the postischemic functional and metabolic disorders in the brain of rats with different sensitivity to hypoxia.

Zarubina IV, Shabanov PD

Bulletin of experimental biology and medicine1 Mar 2009

PMID19529857DOI10.1007/s10517-009-0504-4PepBankPUB-19529857

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In ischemic rats with high or low hypoxia sensitivity, Noopept reduced neurological disorders.
In plain wordsIn rats with brain ischemia, Noopept reduced neurological disorders in both hypoxia sensitivity groups.
Peptide
Noopept (omberacetam)
Outcome
DecreaseNeurological disorders
Study
ratn: not reported in source
Wistar rats with bilateral carotid artery ligation
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
0.5 mg/kg · injection · 7 daysAs given in this study (rat).
Source sentences
Summary
Noopept (peptide preparation), injected (0.5 mg/kg) during 7 days after occlusion of the carotid arteries, reduced the neurological disorders in rats with high and low sensitivity to hypoxia and improved their survival during the postischemic period.
1 context sentence(design, population, supporting numbers)
Summary · context
Chronic cerebral ischemia was induced by ligation of both common carotid arteries in Wistar rats, divided by sensitivity to hypoxia into highly sensitive and low-sensitive.
Report a problemFND-1952985701
02AnimalAnimal study (in vivo)Efficacy outcome
In ischemic rats with high or low hypoxia sensitivity, Noopept improved postischemic survival.
In plain wordsIn rats with brain ischemia, Noopept improved survival in both hypoxia sensitivity groups.
Peptide
Noopept (omberacetam)
Outcome
IncreasePostischemic survival
Study
ratn: not reported in source
Wistar rats with bilateral carotid artery ligation
Outcome group
Mortality · Whole body
Studied dose
0.5 mg/kg · injection · 7 daysAs given in this study (rat).
Source sentences
Summary
Noopept (peptide preparation), injected (0.5 mg/kg) during 7 days after occlusion of the carotid arteries, reduced the neurological disorders in rats with high and low sensitivity to hypoxia and improved their survival during the postischemic period.
1 context sentence(design, population, supporting numbers)
Summary · context
Chronic cerebral ischemia was induced by ligation of both common carotid arteries in Wistar rats, divided by sensitivity to hypoxia into highly sensitive and low-sensitive.
Report a problemFND-1952985702
03AnimalAnimal study (in vivo)Efficacy outcome
In ischemic rats, Noopept normalized behavior measured by the open field test.
In plain wordsIn rats with brain ischemia, Noopept normalized behavior in the open field test.
Peptide
Noopept (omberacetam)
Outcome
MixedOpen field behavior
Study
ratn: not reported in source
Wistar rats with bilateral carotid artery ligation
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
0.5 mg/kg · injection · 7 daysAs given in this study (rat).
Source sentences
Summary
Noopept normalized behavior disordered by cerebral ischemia (according to the open field and elevated plus maze tests), prevented accumulation of LPO products and inhibition of antioxidant systems in the brain of rats with high and low sensitivity to hypoxia.
1 context sentence(design, population, supporting numbers)
Summary · context
Chronic cerebral ischemia was induced by ligation of both common carotid arteries in Wistar rats, divided by sensitivity to hypoxia into highly sensitive and low-sensitive.
Report a problemFND-1952985703
04AnimalAnimal study (in vivo)Efficacy outcome
In ischemic rats, Noopept normalized behavior measured by the elevated plus maze test.
In plain wordsIn rats with brain ischemia, Noopept normalized behavior in the elevated plus maze test.
Peptide
Noopept (omberacetam)
Outcome
MixedElevated plus maze behavior
Study
ratn: not reported in source
Wistar rats with bilateral carotid artery ligation
Outcome group
Anxiety and mood · Nervous system and cognition
Studied dose
0.5 mg/kg · injection · 7 daysAs given in this study (rat).
Source sentences
Summary
Noopept normalized behavior disordered by cerebral ischemia (according to the open field and elevated plus maze tests), prevented accumulation of LPO products and inhibition of antioxidant systems in the brain of rats with high and low sensitivity to hypoxia.
1 context sentence(design, population, supporting numbers)
Summary · context
Chronic cerebral ischemia was induced by ligation of both common carotid arteries in Wistar rats, divided by sensitivity to hypoxia into highly sensitive and low-sensitive.
Report a problemFND-1952985704
05AnimalAnimal study (in vivo)Efficacy outcome
In ischemic rats with high or low hypoxia sensitivity, Noopept prevented accumulation of brain lipid peroxidation products.
In plain wordsIn rats with brain ischemia, Noopept prevented accumulation of lipid oxidation products in the brain.
Peptide
Noopept (omberacetam)
Outcome
DecreaseBrain lipid peroxidation products
Study
ratn: not reported in source
Wistar rats with bilateral carotid artery ligation
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
0.5 mg/kg · injection · 7 daysAs given in this study (rat).
Source sentences
Summary
Noopept normalized behavior disordered by cerebral ischemia (according to the open field and elevated plus maze tests), prevented accumulation of LPO products and inhibition of antioxidant systems in the brain of rats with high and low sensitivity to hypoxia.
1 context sentence(design, population, supporting numbers)
Summary · context
Chronic cerebral ischemia was induced by ligation of both common carotid arteries in Wistar rats, divided by sensitivity to hypoxia into highly sensitive and low-sensitive.
Report a problemFND-1952985705
06AnimalAnimal study (in vivo)Efficacy outcome
In ischemic rats with high or low hypoxia sensitivity, Noopept prevented inhibition of brain antioxidant systems.
In plain wordsIn rats with brain ischemia, Noopept prevented inhibition of brain antioxidant systems.
Peptide
Noopept (omberacetam)
Outcome
IncreaseBrain antioxidant systems
Study
ratn: not reported in source
Wistar rats with bilateral carotid artery ligation
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
0.5 mg/kg · injection · 7 daysAs given in this study (rat).
Source sentences
Summary
Noopept normalized behavior disordered by cerebral ischemia (according to the open field and elevated plus maze tests), prevented accumulation of LPO products and inhibition of antioxidant systems in the brain of rats with high and low sensitivity to hypoxia.
1 context sentence(design, population, supporting numbers)
Summary · context
Chronic cerebral ischemia was induced by ligation of both common carotid arteries in Wistar rats, divided by sensitivity to hypoxia into highly sensitive and low-sensitive.
Report a problemFND-1952985706

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

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MeSH terms

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