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Study · Measured the body's own peptide · 2009

3 results

Involvement of the transcription factor STAT1 in the regulation of porcine ovarian granulosa cell functions treated and not treated with ghrelin.

Benco A, Sirotkin AV, Vasícek D, Pavlová S, Zemanová J, Kotwica J, Darlak K, Valenzuela F

Reproduction (Cambridge, England)15 Jun 2009Cited by 18 (Europe PMC)

PMID19528263 (opens in a new tab)DOI10.1530/rep-08-0313 (opens in a new tab)PepBankPUB-19528263
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Mechanism

    In cultured porcine ovarian granulosa cells, ghrelin given alone increased release of the cells' own oxytocin.

    In plain wordsIn pig ovarian cells, ghrelin raised the release of the cells' own oxytocin.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin release after ghrelin
    Study

    pign: not reported in source

    Cultured porcine ovarian granulosa cells
    Comparator
    Untreated control cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    It was found that ghrelin, when given alone, increased the expression of proliferation-associated PCNA and MAPK/ERK1,2, decreased the accumulation of apoptosis-related substances caspase-3, BAX, BCL2, decreased P(4), and increased PGF and OXT release.
    1 context sentence
    Summary · context
    in cultured porcine ovarian granulosa cells was evaluated using RIA

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Mechanism

    In cultured porcine ovarian granulosa cells, STAT1 overexpression promoted release of the cells' own oxytocin.

    In plain wordsIn pig ovarian cells, extra STAT1 raised the release of the cells' own oxytocin.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin release after STAT1 overexpression
    Study

    pign: not reported in source

    Cultured porcine ovarian granulosa cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Transfection of porcine granulosa cells by a gene construct encoding STAT1 promoted the expression of STAT1 and apoptosis-related-BAX but the expression of BCL2 did not, and decreased the accumulation of proliferation-associated MAPK/ERK1,2 but not that of PCNA. It also promoted PGF and OXT but not P(4) release.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelIn vitro (cells)Mechanism

    In cultured porcine ovarian granulosa cells, STAT1 overexpression reversed the effect of ghrelin on oxytocin release from stimulatory to inhibitory.

    In plain wordsIn pig ovarian cells, extra STAT1 turned the ghrelin effect on the cells' own oxytocin release from raising to lowering.

    Peptide
    Oxytocin
    Outcome
    MixedOxytocin release after ghrelin with STAT1 overexpression
    Study

    pign: not reported in source

    Cultured porcine ovarian granulosa cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Overexpression of STAT1 reversed the effect of ghrelin on STAT1, PCNA, PGF, OXT (from stimulatory to inhibitory)

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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