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Study · In vitro (cell-free) · 2008

3 results

Melting of DNA double strand after binding to geroprotective tetrapeptide.

Khavinson VKh, Solovyov AY, Shataeva LK

Bulletin of experimental biology and medicine1 Nov 2008Cited by 6 (Europe PMC)

PMID19526107 (opens in a new tab)DOI10.1007/s10517-009-0342-4 (opens in a new tab)PepBankPUB-19526107
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Activity measurement

    In a cell-free assay, the hyperchromic effect of duplex DNA with Ala-Glu-Asp-Gly peptide followed a saturation isotherm.

    In plain wordsIn lab tests without cells, the effect of the peptide AEDG on DNA light absorbance levelled off as more peptide was added.

    Peptide
    Epitalon
    Outcome
    Not applicableHyperchromic effect of DNA with AEDG
    Study

    n: not reported in source

    poly(dA-dT):poly(dA-dT) duplex DNA
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Experimental relationship between the hyperchromic effect of DNA [poly(dA-dT):poly(dA-dT)] interacting with Ala-Glu-Asp-Gly peptide is presented by a saturation isotherm.
  2. 02LabIn vitro (cell-free)Activity measurement

    In a cell-free assay, the DNA-AEDG complex melted at 28 degrees C, against 69.5 degrees C for free duplex DNA.

    In plain wordsIn lab tests without cells, DNA bound to the peptide AEDG melted at a lower temperature than free DNA.

    Peptide
    Epitalon
    Outcome
    DecreaseMelting temperature of DNA-peptide complex
    Study

    n: not reported in source

    poly(dA-dT):poly(dA-dT) duplex DNA
    Comparator
    Free DNA
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    Melting temperature
    69.5 degrees C
    free DNA
    Melting temperature
    28 degrees C
    DNA-peptide complex

    Source sentences

    Summary
    The free DNA double strand is melting (the strands separate) at 69.5 degrees C and at higher energy expenditures (enthalpy increase by 976.4 kJ/mol b.p.) in comparison with melting of the DNA-peptide complex (28 degrees C and 444.6 kJ/mol b.p.).
  3. 03LabIn vitro (cell-free)Activity measurement

    In a cell-free assay, melting of the DNA-AEDG complex needed 444.6 kJ/mol b.p., against 976.4 kJ/mol b.p. for free duplex DNA.

    In plain wordsIn lab tests without cells, melting DNA bound to the peptide AEDG took less energy than melting free DNA.

    Peptide
    Epitalon
    Outcome
    DecreaseMelting enthalpy of DNA-peptide complex
    Study

    n: not reported in source

    poly(dA-dT):poly(dA-dT) duplex DNA
    Comparator
    Free DNA
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    Melting enthalpy
    976.4 kJ/mol b.p.
    free DNA
    Melting enthalpy
    444.6 kJ/mol b.p.
    DNA-peptide complex

    Source sentences

    Summary
    The free DNA double strand is melting (the strands separate) at 69.5 degrees C and at higher energy expenditures (enthalpy increase by 976.4 kJ/mol b.p.) in comparison with melting of the DNA-peptide complex (28 degrees C and 444.6 kJ/mol b.p.).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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