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Study · Measured the body's own peptide · 2009

5 results

Gingival crevicular fluid levels of cathelicidin LL-37 and interleukin-18 in patients with chronic periodontitis.

Türkoğlu O, Emingil G, Kütükçüler N, Atilla G

Journal of periodontology1 Jun 2009Cited by 80 (Europe PMC)

PMID19485828 (opens in a new tab)DOI10.1902/jop.2009.080532 (opens in a new tab)PepBankPUB-19485828
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In people with chronic periodontitis, gingival crevicular fluid levels of the body's own cathelicidin LL‑37 were significantly higher than in the gingivitis and healthy groups.

    In plain wordsIn people with gum disease, the body's own LL‑37 in gum fluid was higher than in other groups.

    Peptide
    LL-37
    Outcome
    IncreaseGCF cathelicidin LL-37 level in chronic periodontitis
    Study

    n = 59

    Comparator
    Gingivitis and healthy controls
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    GCF levels of cathelicidin LL-37 were significantly elevated in patients with chronic periodontitis compared to the other groups (P <0.05).
    2 context sentences
    Summary · context
    Fifty-nine subjects were included in the present study.
    Summary · context
    Probing depth (PD), clinical attachment level (CAL), plaque index (PI), bleeding on probing, and papilla bleeding index (PBI) were assessed in patients with chronic periodontitis or gingivitis and in healthy controls.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In people with periodontal disease, gingival crevicular fluid LL‑37 correlated positively with probing depth at the sampled sites.

    In plain wordsHigher natural LL‑37 in gum fluid was linked to deeper gum pockets.

    Peptide
    LL-37
    Outcome
    IncreaseCorrelation of GCF LL-37 with probing depth
    Study

    n = 59

    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    Spearman correlation analysis revealed a positive relationship between levels of GCF cathelicidin LL-37 and PD, CAL, PI, and PBI at the sampled sites (P 0.05).
    2 context sentences
    Summary · context
    Fifty-nine subjects were included in the present study.
    Summary · context
    Probing depth (PD), clinical attachment level (CAL), plaque index (PI), bleeding on probing, and papilla bleeding index (PBI) were assessed in patients with chronic periodontitis or gingivitis and in healthy controls.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In people with periodontal disease, gingival crevicular fluid LL‑37 correlated positively with clinical attachment level at the sampled sites.

    In plain wordsHigher natural LL‑37 in gum fluid was linked to more attachment loss.

    Peptide
    LL-37
    Outcome
    IncreaseCorrelation of GCF LL-37 with clinical attachment level
    Study

    n = 59

    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    Spearman correlation analysis revealed a positive relationship between levels of GCF cathelicidin LL-37 and PD, CAL, PI, and PBI at the sampled sites (P 0.05).
    2 context sentences
    Summary · context
    Fifty-nine subjects were included in the present study.
    Summary · context
    Probing depth (PD), clinical attachment level (CAL), plaque index (PI), bleeding on probing, and papilla bleeding index (PBI) were assessed in patients with chronic periodontitis or gingivitis and in healthy controls.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In people with periodontal disease, gingival crevicular fluid LL‑37 correlated positively with plaque index at the sampled sites.

    In plain wordsHigher natural LL‑37 in gum fluid was linked to more plaque.

    Peptide
    LL-37
    Outcome
    IncreaseCorrelation of GCF LL-37 with plaque index
    Study

    n = 59

    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    Spearman correlation analysis revealed a positive relationship between levels of GCF cathelicidin LL-37 and PD, CAL, PI, and PBI at the sampled sites (P 0.05).
    2 context sentences
    Summary · context
    Fifty-nine subjects were included in the present study.
    Summary · context
    Probing depth (PD), clinical attachment level (CAL), plaque index (PI), bleeding on probing, and papilla bleeding index (PBI) were assessed in patients with chronic periodontitis or gingivitis and in healthy controls.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelObservational studyOther

    In people with periodontal disease, gingival crevicular fluid LL‑37 correlated positively with papilla bleeding index at the sampled sites.

    In plain wordsHigher natural LL‑37 in gum fluid was linked to more gum bleeding.

    Peptide
    LL-37
    Outcome
    IncreaseCorrelation of GCF LL-37 with papilla bleeding index
    Study

    n = 59

    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    Spearman correlation analysis revealed a positive relationship between levels of GCF cathelicidin LL-37 and PD, CAL, PI, and PBI at the sampled sites (P 0.05).
    2 context sentences
    Summary · context
    Fifty-nine subjects were included in the present study.
    Summary · context
    Probing depth (PD), clinical attachment level (CAL), plaque index (PI), bleeding on probing, and papilla bleeding index (PBI) were assessed in patients with chronic periodontitis or gingivitis and in healthy controls.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase not statedNCT04404335

The Role of Anti-inflammatory Cytokines and Antimicrobial Peptide LL-37 Biomarkers in the Treatment of Periodontal Disease.

Universidad Rey Juan Carlosn = 6017 May 2021 to 15 Jul 2022

Periodontal Diseases · Periodontitis

Trial pageClinicalTrials.govUpdated 30 Sept 2022

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:58 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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