Study · Animal study (in vivo) · rat · 2009

1 result

Melanocortin-4 receptor activation inhibits c-Jun N-terminal kinase activity and promotes insulin signaling.

Chai B, Li JY, Zhang W, Wang H, Mulholland MW

Peptides25 Mar 2009Cited by 36 (Europe PMC)

PMID19463742PMCIDPMC2687409DOI10.1016/j.peptides.2009.03.006PepBankPUB-19463742

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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats, melanotan II increased insulin-stimulated AKT phosphorylation in the hypothalamus.
In plain wordsIn rats, melanotan II increased the insulin-driven AKT signal in the hypothalamus.
Peptide
Melanotan II
Outcome
IncreaseInsulin-stimulated AKT phosphorylation in hypothalamus
Study
ratn: not reported in source
in vivo, rat hypothalamus
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
The melanocortin agonist melanotan II increased insulin-stimulated AKT phosphorylation in the rat hypothalamus in vivo.
Report a problemFND-1946374201

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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