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Study · Randomized controlled trial · n = 24 · 2009

2 results

Preservation of GHRH and GH-releasing peptide-2 efficacy in young men with experimentally induced hypogonadism.

Veldhuis JD, Keenan DM, Bailey JN, Miles JM, Bowers CY

European journal of endocrinology20 May 2009Cited by 5 (Europe PMC)

PMID19458139 (opens in a new tab)PMCIDPMC2772823 (opens in a new tab)DOI10.1530/eje-09-0270 (opens in a new tab)PepBankPUB-19458139
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In young men with experimental hypogonadism, GH secretion stimulated by L-arginine/GHRP‑2 was unaffected by combined testosterone and estradiol depletion.

    In plain wordsIn young men with temporarily low sex hormones, the GH response to GHRP‑2 stayed the same.

    Peptide
    GHRP-2
    Outcome
    No significant changeGH secretion stimulated by L-arginine/GHRP-2 during testosterone/estradiol depletion
    Study

    n = 24

    Comparator
    Testosterone addback
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    GH secretion stimulated by l-arginine/GHRH and by l-arginine/GHRP-2 was unaffected by combined testosterone/estradiol (E(2)) depletion.
    2 context sentences
    Summary · context
    Prospective, randomized double-blind.
    Summary · context
    Healthy young men (n=24) received a GnRH agonist twice 3 weeks apart followed by placebo (n=13, Pl) or testosterone (n=11, testosterone) addback.
  2. 02HumanRandomized controlled trialMechanism

    In young men with experimental hypogonadism, responses to GHRP‑2 were unrelated to abdominal visceral fat, IGF1, IGFBP-1 or IGFBP-3.

    In plain wordsIn young men with temporarily low sex hormones, the GH response to GHRP‑2 was not linked to belly fat or IGF levels.

    Peptide
    GHRP-2
    Outcome
    No significant changeAssociation of GHRP-2 responses with AVF, IGF1 and IGFBPs
    Study

    n = 24

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    Responses to GHRP-2 were unrelated to any of these factors.
    3 context sentences
    Summary · context
    AVF (P=0.0024) was a negative determinant, and IGF1 a positive determinant (P=0.018), of GHRH-driven GH pulses.
    Summary · context
    Prospective, randomized double-blind.
    Summary · context
    Healthy young men (n=24) received a GnRH agonist twice 3 weeks apart followed by placebo (n=13, Pl) or testosterone (n=11, testosterone) addback.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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