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Study · Randomized controlled trial · n = 26 · 2009

2 results

Oxytocin enhances the experience of attachment security.

Buchheim A, Heinrichs M, George C, Pokorny D, Koops E, Henningsen P, O'Connor MF, Gündel H

Psychoneuroendocrinology19 May 2009Cited by 161 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In insecurely attached healthy men, a single intranasal oxytocin dose raised the ranking of secure attachment phrases and lowered the ranking of insecure phrases in 18 of 26 subjects versus placebo.

    In plain wordsIn insecurely attached healthy men, one nasal dose of oxytocin raised the sense of attachment security in most subjects, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseAttachment security ranking of AAP secure phrases
    Study

    n = 26

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasal · single doseAs given in this study (human).

    Measurements

    Subjects with increased secure ranking
    18 subjects
    oxytocin condition
    Proportion of subjects with increased secure ranking
    69%
    oxytocin condition

    Source sentences

    Summary
    In the oxytocin condition, a significant proportion of these insecure subjects (N=18; 69%) increased in their rankings of the AAP prototypical "secure attachment" phrases and decreased in overall ranking of the "insecure attachment" phrases.
    2 context sentences
    Summary · context
    Within a 3-week interval, 26 healthy male students classified with an insecure attachment pattern were invited twice to an experimental session.
    Summary · context
    At the beginning of each experiment, a single dose of oxytocin or placebo was administered intranasally, using a double-blind, placebo-controlled within-subject design.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In insecurely attached healthy men, fewer subjects ranked the pictures with insecure-preoccupied phrases after intranasal oxytocin than after placebo.

    In plain wordsIn insecurely attached healthy men, fewer chose insecure-preoccupied phrases after nasal oxytocin than after placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseInsecure-preoccupied phrase ranking
    Study

    n = 26

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    In particular, there was a significant decrease in the number of subjects ranking the pictures with "insecure-preoccupied" phrases from the placebo to the oxytocin condition.
    2 context sentences
    Summary · context
    Within a 3-week interval, 26 healthy male students classified with an insecure attachment pattern were invited twice to an experimental session.
    Summary · context
    At the beginning of each experiment, a single dose of oxytocin or placebo was administered intranasally, using a double-blind, placebo-controlled within-subject design.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 stopped early · source ClinicalTrials.gov (opens in a new tab)

WithdrawnPhase 1NCT01912378

Triadic Interactions of Families With Autism and Oxytocin

University of California, San Franciscon = 0Aug 2013 to May 2015

Autism Disorder

Trial pageClinicalTrials.govUpdated 16 Jan 2019

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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