[The influence of melatonin and epithalon on blood leukocyte count and leukocyte alkaline phosphatase in rats under different lighting conditions during ontogenesis].

Uzenbaeva LB, Vinogradova IA, Golubeva AG, Niuppieva MG, Iliukha VA

Advances in gerontology = Uspekhi gerontologii1 Jan 2008Cited by 1 (Europe PMC)

PMID19432172PepBankPUB-19432172

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, epithalon significantly reduced the number of lymphocytes in some age period, unlike melatonin.
In plain wordsIn rats, epithalon lowered lymphocyte numbers in some age periods, unlike melatonin.
Peptide
Epitalon
Outcome
DecreaseLymphocyte number with epithalon
Study
ratn: not reported in source
Rats under different lighting conditions
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
epithalon significantly reduces the number of lymphocytes and increases the number of neutrophils in some age period.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of pineal body hormone melatonin and synthetic tetrapeptide epithalon (Ala-Glu-Asp-Gly) under different light conditions on leucocytes differential count in rats were investigated.
Report a problemFND-1943217203
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, epithalon increased the number of neutrophils in some age period.
In plain wordsIn rats, epithalon raised neutrophil numbers in some age periods.
Peptide
Epitalon
Outcome
IncreaseNeutrophil number with epithalon
Study
ratn: not reported in source
Rats under different lighting conditions
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
and increases the number of neutrophils in some age period.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of pineal body hormone melatonin and synthetic tetrapeptide epithalon (Ala-Glu-Asp-Gly) under different light conditions on leucocytes differential count in rats were investigated.
Report a problemFND-1943217204

Studies that did not test the peptide alone3

In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Epitalon.

03AnimalNot a test of Epitalon aloneAnimal study (in vivo)Efficacy outcome
In 12-month-old rats, melatonin and epithalon decreased the level of blood leucocytes, and the effect was higher in constant light.
In plain wordsIn 12-month-old rats, melatonin and epithalon lowered white blood cell levels, more so under constant light.
Peptide
Epitalon
Outcome
DecreaseBlood leucocyte level in 12-month rats
Study
ratn: not reported in source
Rats under different lighting conditions
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
It has been established that melatonin and epithalon decrease the level of blood leucocytes
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of pineal body hormone melatonin and synthetic tetrapeptide epithalon (Ala-Glu-Asp-Gly) under different light conditions on leucocytes differential count in rats were investigated.
In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.
Report a problemFND-1943217201
04AnimalNot a test of Epitalon aloneAnimal study (in vivo)Efficacy outcome
In 12-month-old rats, melatonin and epithalon decreased the relative content of band neutrophils.
In plain wordsIn 12-month-old rats, melatonin and epithalon lowered the share of band neutrophils.
Peptide
Epitalon
Outcome
DecreaseBand neutrophil content in 12-month rats
Study
ratn: not reported in source
Rats under different lighting conditions
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
relative content of band neutrophils in 12 months rats which was higher in the constant light more than in other photoperiod.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of pineal body hormone melatonin and synthetic tetrapeptide epithalon (Ala-Glu-Asp-Gly) under different light conditions on leucocytes differential count in rats were investigated.
In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.
Report a problemFND-1943217202
05AnimalNot a test of Epitalon aloneAnimal study (in vivo)Efficacy outcome
In rats under standard and natural light, melatonin and epithalon showed an adjacency effect on the increase of alkaline phosphatase activity in leucocytes.
In plain wordsIn rats, melatonin and epithalon were linked with changes in leukocyte alkaline phosphatase activity under standard and natural light.
Peptide
Epitalon
Outcome
MixedLeukocyte alkaline phosphatase activity
Study
ratn: not reported in source
Rats under different lighting conditions
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
The melatonin and epithalon adjacency effect on increasing of alkaline phosphatase activity under the standard as well as natural light condition demonstrate homeostatic character of geroprotectors action furthermore depend on leucocytes functional status.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of pineal body hormone melatonin and synthetic tetrapeptide epithalon (Ala-Glu-Asp-Gly) under different light conditions on leucocytes differential count in rats were investigated.
In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.
Report a problemFND-1943217205

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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