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Study · Animal study (in vivo) · chicken · 2008

8 results

[Effects of epithalon and cortagene on immunity and hemostasis in neonatally hypophysectomized chicken and old birds].

Kuznik BI, Pateiuk AV, Baranchugova LM, Rusaeva NS

Advances in gerontology = Uspekhi gerontologii1 Jan 2008Cited by 1 (Europe PMC)

PMID19432169 (opens in a new tab)PepBankPUB-19432169
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In hypophysectomized chicken and old birds, 40 days of epithalon injections completely eliminated the shifts in erythrocytes.

    In plain wordsIn chickens with the pituitary gland removed and in old birds, epithalon injections removed the changes in red blood cells.

    Peptide
    Epitalon
    Outcome
    IncreaseErythrocyte shifts
    Study

    chickenn: not reported in source

    Neonatally hypophysectomized chicken and old birds
    Outcome group
    Overall treatment effect · Whole body
    Studied dose
    Dose not stated · injection · 40 daysAs given in this study (chicken).

    Source sentences

    Summary
    Injections of epithalon tetrapeptide (Ala-Glu-Asp-Gly) administered to either hypophysectomized chicken or old birds during a period of 40 days completely eliminate the shifts registered in erythrocytes, immunity and hemostasis
    1 context sentence
    Summary · context
    It has been found that chicken hypophysectomized early in the neonatal period develop anemia, cellular and humoral immune deficiency, hypercoagulation and inhibited fibrinolysis by their 45th postnatal day.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In hypophysectomized chicken and old birds, 40 days of epithalon injections completely eliminated the shifts in immunity.

    In plain wordsIn chickens with the pituitary gland removed and in old birds, epithalon injections removed the changes in immune measures.

    Peptide
    Epitalon
    Outcome
    IncreaseImmunity shifts
    Study

    chickenn: not reported in source

    Neonatally hypophysectomized chicken and old birds
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · injection · 40 daysAs given in this study (chicken).

    Source sentences

    Summary
    Injections of epithalon tetrapeptide (Ala-Glu-Asp-Gly) administered to either hypophysectomized chicken or old birds during a period of 40 days completely eliminate the shifts registered in erythrocytes, immunity and hemostasis
    1 context sentence
    Summary · context
    It has been found that chicken hypophysectomized early in the neonatal period develop anemia, cellular and humoral immune deficiency, hypercoagulation and inhibited fibrinolysis by their 45th postnatal day.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In hypophysectomized chicken and old birds, 40 days of epithalon injections completely eliminated the shifts in hemostasis.

    In plain wordsIn chickens with the pituitary gland removed and in old birds, epithalon injections removed the changes in blood clotting measures.

    Peptide
    Epitalon
    Outcome
    MixedHemostasis shifts
    Study

    chickenn: not reported in source

    Neonatally hypophysectomized chicken and old birds
    Outcome group
    Bleeding and clotting · Cardiovascular
    Studied dose
    Dose not stated · injection · 40 daysAs given in this study (chicken).

    Source sentences

    Summary
    Injections of epithalon tetrapeptide (Ala-Glu-Asp-Gly) administered to either hypophysectomized chicken or old birds during a period of 40 days completely eliminate the shifts registered in erythrocytes, immunity and hemostasis
    1 context sentence
    Summary · context
    It has been found that chicken hypophysectomized early in the neonatal period develop anemia, cellular and humoral immune deficiency, hypercoagulation and inhibited fibrinolysis by their 45th postnatal day.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In hypophysectomized chickens and old birds, cortagene injections did not affect erythrocyte parameters.

    In plain wordsIn chickens and old birds, cortagene injections did not affect erythrocyte parameters.

    Peptide
    Cortagen (AEDP)
    Outcome
    No significant changeErythrocyte parameters
    Study

    chickenn: not reported in source

    Neonatally hypophysectomized chickens and old birds
    Outcome group
    Blood counts and hematopoiesis · Whole body
    Studied dose
    Dose not stated · injectionAs given in this study (chicken).

    Source sentences

    Summary
    while injections of cortagene (Ala-Glu-Asp-Pro) which is distinguished from epithalon by a different terminal aminoacid (with Gly being replaced by Pro) do not affect the parameters studied.
    1 context sentence
    Summary · context
    It has been found that chicken hypophysectomized early in the neonatal period develop anemia, cellular and humoral immune deficiency, hypercoagulation and inhibited fibrinolysis by their 45th postnatal day. An analogous operation performed on old birds produces less significant changes in erythrocyt…
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In hypophysectomized chickens and old birds, cortagene injections did not affect cellular immunity.

    In plain wordsIn chickens and old birds, cortagene injections did not affect cellular immunity.

    Peptide
    Cortagen (AEDP)
    Outcome
    No significant changeCellular immunity
    Study

    chickenn: not reported in source

    Neonatally hypophysectomized chickens and old birds
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · injectionAs given in this study (chicken).

    Source sentences

    Summary
    while injections of cortagene (Ala-Glu-Asp-Pro) which is distinguished from epithalon by a different terminal aminoacid (with Gly being replaced by Pro) do not affect the parameters studied.
    1 context sentence
    Summary · context
    It has been found that chicken hypophysectomized early in the neonatal period develop anemia, cellular and humoral immune deficiency, hypercoagulation and inhibited fibrinolysis by their 45th postnatal day. An analogous operation performed on old birds produces less significant changes in erythrocyt…
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In hypophysectomized chickens and old birds, cortagene injections did not affect humoral immunity.

    In plain wordsIn chickens and old birds, cortagene injections did not affect humoral immunity.

    Peptide
    Cortagen (AEDP)
    Outcome
    No significant changeHumoral immunity
    Study

    chickenn: not reported in source

    Neonatally hypophysectomized chickens and old birds
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · injectionAs given in this study (chicken).

    Source sentences

    Summary
    while injections of cortagene (Ala-Glu-Asp-Pro) which is distinguished from epithalon by a different terminal aminoacid (with Gly being replaced by Pro) do not affect the parameters studied.
    1 context sentence
    Summary · context
    It has been found that chicken hypophysectomized early in the neonatal period develop anemia, cellular and humoral immune deficiency, hypercoagulation and inhibited fibrinolysis by their 45th postnatal day. An analogous operation performed on old birds produces less significant changes in erythrocyt…
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In hypophysectomized chickens and old birds, cortagene injections did not affect coagulation parameters.

    In plain wordsIn chickens and old birds, cortagene injections did not affect coagulation parameters.

    Peptide
    Cortagen (AEDP)
    Outcome
    No significant changeCoagulation
    Study

    chickenn: not reported in source

    Neonatally hypophysectomized chickens and old birds
    Outcome group
    Bleeding and clotting · Cardiovascular
    Studied dose
    Dose not stated · injectionAs given in this study (chicken).

    Source sentences

    Summary
    while injections of cortagene (Ala-Glu-Asp-Pro) which is distinguished from epithalon by a different terminal aminoacid (with Gly being replaced by Pro) do not affect the parameters studied.
    1 context sentence
    Summary · context
    It has been found that chicken hypophysectomized early in the neonatal period develop anemia, cellular and humoral immune deficiency, hypercoagulation and inhibited fibrinolysis by their 45th postnatal day. An analogous operation performed on old birds produces less significant changes in erythrocyt…
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In hypophysectomized chickens and old birds, cortagene injections did not affect fibrinolysis.

    In plain wordsIn chickens and old birds, cortagene injections did not affect fibrinolysis.

    Peptide
    Cortagen (AEDP)
    Outcome
    No significant changeFibrinolysis
    Study

    chickenn: not reported in source

    Neonatally hypophysectomized chickens and old birds
    Outcome group
    Bleeding and clotting · Cardiovascular
    Studied dose
    Dose not stated · injectionAs given in this study (chicken).

    Source sentences

    Summary
    while injections of cortagene (Ala-Glu-Asp-Pro) which is distinguished from epithalon by a different terminal aminoacid (with Gly being replaced by Pro) do not affect the parameters studied.
    1 context sentence
    Summary · context
    It has been found that chicken hypophysectomized early in the neonatal period develop anemia, cellular and humoral immune deficiency, hypercoagulation and inhibited fibrinolysis by their 45th postnatal day. An analogous operation performed on old birds produces less significant changes in erythrocyt…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 10Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 7 times, first on 21 Oct 2026, 17:05 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    21 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    12 Oct 2026, 17:28 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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