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Study · Animal study (in vivo) · dog · 2009

1 result

Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase.

Sasaki H, Asanuma H, Fujita M, Takahama H, Wakeno M, Ito S, Ogai A, Asakura M, Kim J, Minamino T, Takashima S, Sanada S and 4 more

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Sugimachi M, Komamura K, Mochizuki N, Kitakaze M

Circulation4 May 2009Cited by 259 (Europe PMC)

PMID19414638 (opens in a new tab)DOI10.1161/circulationaha.108.798561 (opens in a new tab)PepBankPUB-19414638
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In the heart failure study, AICAR had effects equivalent to metformin on reducing apoptosis and preventing heart failure.

    In plain wordsIn dogs, AICAR's effects on apoptosis and heart failure prevention were equivalent to metformin's effects.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeAntiapoptotic and heart failure effects
    Study

    dogn: not reported in source

    failing canine hearts
    Comparator
    metformin
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, another AMPK activator (AICAR) had effects equivalent to those of metformin, suggesting the primary role of AMPK activation in reducing apoptosis and preventing heart failure.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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