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Study · Animal study (in vivo) · mouse · 2009

4 results

PGC-1alpha mediates exercise-induced skeletal muscle VEGF expression in mice.

Leick L, Hellsten Y, Fentz J, Lyngby SS, Wojtaszewski JF, Hidalgo J, Pilegaard H

American journal of physiology. Endocrinology and metabolism28 Apr 2009Cited by 98 (Europe PMC)

PMID19401459 (opens in a new tab)DOI10.1152/ajpendo.00076.2009 (opens in a new tab)PepBankPUB-19401459
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In wild-type mice, AICAR increased skeletal muscle VEGF mRNA content compared with saline.

    In plain wordsIn mice with intact PGC-1alpha, AICAR increased muscle VEGF messenger RNA compared with no AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseVEGF mRNA in wild-type mice
    Study

    mousen: not reported in source

    PGC-1alpha knockout and wild-type skeletal muscle
    Comparator
    saline-treated wild-type mice
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneous · 4 wkAs given in this study (mouse).

    Source sentences

    Summary
    Basal VEGF mRNA expression was similar in WT and PGC-1alpha KO mice, but acute exercise and AICAR treatment increased the VEGF mRNA content in WT mice only.
    1 context sentence
    Summary · context
    Whole body PGC-1alpha knockout (KO) and littermate wild-type (WT) mice were submitted to either 1) 5 wk of exercise training, 2) lifelong (from 2 to 13 mo of age) exercise training in activity wheel, 3) a single exercise bout, or 4) 4 wk of daily subcutaneous AICAR or saline injections.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In wild-type mice, repeated AICAR increased skeletal muscle VEGF protein expression approximately 15% compared with saline.

    In plain wordsIn mice with intact PGC-1alpha, repeated AICAR increased muscle VEGF protein by approximately 15% compared with no AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseVEGF protein in wild-type mice
    Study

    mousen: not reported in source

    PGC-1alpha knockout and wild-type skeletal muscle
    Comparator
    saline-treated wild-type mice
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneous · 4 wkAs given in this study (mouse).

    Measurements

    VEGF protein expression increase
    ≈ 15%
    WT mice

    Source sentences

    Summary
    In addition, repeated AICAR treatments increased skeletal muscle VEGF protein expression approximately 15% in WT but not in PGC-1alpha KO mice.
    1 context sentence
    Summary · context
    Whole body PGC-1alpha knockout (KO) and littermate wild-type (WT) mice were submitted to either 1) 5 wk of exercise training, 2) lifelong (from 2 to 13 mo of age) exercise training in activity wheel, 3) a single exercise bout, or 4) 4 wk of daily subcutaneous AICAR or saline injections.

Studies that did not test the peptide alone2

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 03AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In PGC-1alpha knockout mice, AICAR treatment did not increase skeletal muscle VEGF mRNA content.

    In plain wordsIn mice without PGC-1alpha, AICAR did not increase muscle VEGF messenger RNA compared with no AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeVEGF mRNA in knockout mice
    Study

    mousen: not reported in source

    PGC-1alpha knockout and wild-type skeletal muscle
    Comparator
    saline-treated PGC-1alpha knockout mice
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    Basal VEGF mRNA expression was similar in WT and PGC-1alpha KO mice, but acute exercise and AICAR treatment increased the VEGF mRNA content in WT mice only.
    1 context sentence
    Summary · context
    Whole body PGC-1alpha knockout (KO) and littermate wild-type (WT) mice were submitted to either 1) 5 wk of exercise training, 2) lifelong (from 2 to 13 mo of age) exercise training in activity wheel, 3) a single exercise bout, or 4) 4 wk of daily subcutaneous AICAR or saline injections.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 04AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In PGC-1alpha knockout mice, repeated AICAR treatment did not increase skeletal muscle VEGF protein expression.

    In plain wordsIn mice without PGC-1alpha, repeated AICAR did not increase muscle VEGF protein compared with no AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeVEGF protein in knockout mice
    Study

    mousen: not reported in source

    PGC-1alpha knockout and wild-type skeletal muscle
    Comparator
    saline-treated PGC-1alpha knockout mice
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    In addition, repeated AICAR treatments increased skeletal muscle VEGF protein expression approximately 15% in WT but not in PGC-1alpha KO mice.
    1 context sentence
    Summary · context
    Whole body PGC-1alpha knockout (KO) and littermate wild-type (WT) mice were submitted to either 1) 5 wk of exercise training, 2) lifelong (from 2 to 13 mo of age) exercise training in activity wheel, 3) a single exercise bout, or 4) 4 wk of daily subcutaneous AICAR or saline injections.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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