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Study · Non-randomized trial · n = 29 · 2009

2 results

Ghrelin and GHRP-6-induced ACTH and cortisol release in thyrotoxicosis.

Nascif SO, Molica P, Correa-Silva SR, Silva MR, Lengyel AM

Pituitary26 Apr 2009Cited by 6 (Europe PMC)

PMID19396632 (opens in a new tab)DOI10.1007/s11102-009-0181-3 (opens in a new tab)PepBankPUB-19396632
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In patients with thyrotoxicosis, the cortisol response to GHRP‑6 was similar to that of controls.

    In plain wordsIn people with an overactive thyroid, the cortisol response to GHRP‑6 was similar to that of controls.

    Peptide
    GHRP-6
    Outcome
    No significant changeDelta AUC cortisol after GHRP-6
    Study

    n = 29

    Comparator
    Controls
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Delta AUC cortisol
    115 microg/dl.90 min
    thyrotoxicosis
    Delta AUC cortisol
    192 microg/dl.90 min
    controls

    Source sentences

    Summary
    In thyrotoxicosis Delta AUC cortisol values (microg/dl.90 min) after ghrelin (484 +/- 80) and GHRP-6 (115 +/- 63) were similar to controls (ghrelin: 524 +/- 107; GHRP-6: 192 +/- 73).
    1 context sentence
    Summary · context
    We evaluated the effects of ghrelin and GHRP-6 on the HPA axis in 20 hyperthyroid patients and in 9 controls.
  2. 02HumanNon-randomized trialEfficacy outcome

    In patients with thyrotoxicosis, the ACTH response to GHRP‑6 was higher than in controls, but not significantly.

    In plain wordsIn people with an overactive thyroid, the ACTH response to GHRP‑6 was higher than in controls, but the difference was not significant.

    Peptide
    GHRP-6
    Outcome
    No significant changeDelta AUC ACTH after GHRP-6
    Study

    n = 29

    Comparator
    Controls
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Delta AUC ACTH
    927 pg/ml x 90 min
    patients
    Delta AUC ACTH
    539 pg/ml x 90 min
    controls

    Source sentences

    Summary
    Delta AUC ACTH values after GHRP-6 were also higher, although not significantly (patients: 927 +/- 330; controls: 539 +/- 237).
    1 context sentence
    Summary · context
    We evaluated the effects of ghrelin and GHRP-6 on the HPA axis in 20 hyperthyroid patients and in 9 controls.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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