In rabbits with Pseudomonas aeruginosa sinusitis, the 24 amino acid LL‑37-derived peptide at 2.5 mg/mL significantly lowered bacterial colony-forming units after 10 days of irrigation.
In plain wordsIn rabbits with sinus infection, a peptide made from LL‑37 at 2.5 mg/mL lowered bacterial counts after 10 days.
- Peptide
- LL-37
- Outcome
- DecreaseBacterial CFU in nasal diluent after 10 days
- Study
rabbitn = 30
Pseudomonas aeruginosa (PAO-1) biofilm sinusitis model with irrigating catheters- Comparator
- Carrier solution without peptide
- Outcome group
- Infection and antimicrobial activity · Infection
Source sentences
Topical tobramycin at 400x minimum inhibitory concentration and 2.5 mg/mL of peptide were effective in significantly lowering CFUs after 10 days of irrigation.
2 context sentences(design, population, supporting numbers)
Five groups of six New Zealand rabbits were each infected with P. aeruginosa (PAO-1) and fitted with irrigating catheters 7 days later.
Each group was instilled with either one of three different concentrations of peptide, a positive control of topical tobramycin, or the carrier solution without the peptide once a day for 10 days.
In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.