Influence of food intake on the bioavailability and efficacy of oral calcitonin.

Karsdal MA, Byrjalsen I, Azria M, Arnold M, Choi L, Riis BJ, Christiansen C

British journal of clinical pharmacology1 Apr 2009Cited by 31 (Europe PMC)

PMID19371314PMCIDPMC2679104DOI10.1111/j.1365-2125.2009.03371.xPepBankPUB-19371314

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

01HumanRandomized controlled trialPharmacokinetics
In healthy postmenopausal women, a meal at 18.00 h reduced salmon calcitonin bioavailability to 26% relative to fasting.
In plain wordsIn postmenopausal women, a meal at 18.00 h reduced salmon calcitonin absorption compared with fasting.
Peptide
Calcitonin-salmon
Outcome
DecreaseBioavailability with meal at 18.00 h
Study
n: not reported in source
Comparator
Fasting
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
0.8 mg · oralAs given in this study (human).
Measurements
Relative bioavailability
26%
meal at 18.00 h
95% CI lower
0.09 relative bioavailability
meal at 18.00 h
95% CI upper
0.73 relative bioavailability
meal at 18.00 h
P value
0.009
meal at 18.00 h
Source sentences
Summary
The predose meal at 18.00 and 21.00 h significantly decreased relative oral bioavailability of sCT to 26% [95% confidence interval (CI) 0.09, 0.73 and 0.09, 0.75, P= 0.009 and P= 0.01].
2 context sentences(design, population, supporting numbers)
Summary · context
A single-blind, randomized, partly placebo-controlled study was conducted in 36 healthy postmenopausal female volunteers aged 62-74 years.
Summary · context
The influence of food intake on oral dosing with 0.8 mg of sCT at 22.00 h was evaluated for a (i) predose meal at 18.00 h, (ii) predose meal at 20.00 h, (iii) predose meal at 21.00 h, (iv) postdose meal at 22.10 h, (v) no meal, and (vi) meal at 20.00 h and placebo at 22.00 h.
Report a problemFND-1937131401
02HumanRandomized controlled trialPharmacokinetics
In healthy postmenopausal women, a meal at 21.00 h reduced salmon calcitonin bioavailability to 26% relative to fasting.
In plain wordsIn postmenopausal women, a meal at 21.00 h reduced salmon calcitonin absorption compared with fasting.
Peptide
Calcitonin-salmon
Outcome
DecreaseBioavailability with meal at 21.00 h
Study
n: not reported in source
Comparator
Fasting
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
0.8 mg · oralAs given in this study (human).
Measurements
Relative bioavailability
26%
meal at 21.00 h
95% CI lower
0.09 relative bioavailability
meal at 21.00 h
95% CI upper
0.75 relative bioavailability
meal at 21.00 h
P value
0.01
meal at 21.00 h
Source sentences
Summary
The predose meal at 18.00 and 21.00 h significantly decreased relative oral bioavailability of sCT to 26% [95% confidence interval (CI) 0.09, 0.73 and 0.09, 0.75, P= 0.009 and P= 0.01].
2 context sentences(design, population, supporting numbers)
Summary · context
A single-blind, randomized, partly placebo-controlled study was conducted in 36 healthy postmenopausal female volunteers aged 62-74 years.
Summary · context
The influence of food intake on oral dosing with 0.8 mg of sCT at 22.00 h was evaluated for a (i) predose meal at 18.00 h, (ii) predose meal at 20.00 h, (iii) predose meal at 21.00 h, (iv) postdose meal at 22.10 h, (v) no meal, and (vi) meal at 20.00 h and placebo at 22.00 h.
Report a problemFND-1937131402
03HumanRandomized controlled trialPharmacokinetics
In postmenopausal women, a meal 10 min after salmon calcitonin dosing reduced relative bioavailability to 59%, without statistical significance.
In plain wordsIn postmenopausal women, absorption with a meal after dosing did not differ significantly from fasting.
Peptide
Calcitonin-salmon
Outcome
No significant changeBioavailability with postdose meal
Study
n: not reported in source
Comparator
Fasting
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
0.8 mg · oralAs given in this study (human).
Measurements
Relative bioavailability
59%
postdose meal
95% CI lower
0.21 relative bioavailability
postdose meal
95% CI upper
1.68 relative bioavailability
postdose meal
P value
0.48
postdose meal
Source sentences
Summary
The meal consumed 10 min after dosing decreased the oral bioavailability of sCT to 59% (95% CI 0.21, 1.68), although nonsignificant (P= 0.48).
1 context sentence(design, population, supporting numbers)
Summary · context
A single-blind, randomized, partly placebo-controlled study was conducted in 36 healthy postmenopausal female volunteers aged 62-74 years.
Report a problemFND-1937131403
04HumanRandomized controlled trialEfficacy outcome
In postmenopausal women, salmon calcitonin suppressed CTX-I less with a meal at 18.00 h than during fasting.
In plain wordsIn postmenopausal women, salmon calcitonin suppressed bone resorption less after a predose meal than during fasting.
Peptide
Calcitonin-salmon
Outcome
DecreaseCTX-I suppression AUC with predose meal
Study
n: not reported in source
Comparator
Fasting
Outcome group
Bone and joint · Musculoskeletal
Studied dose
0.8 mg · oralAs given in this study (human).
Measurements
CTX-I response AUC
−91 %-x-hours
meal at 18.00 h
CTX-I response AUC
−238 %-x-hours
fasting
Adjusted difference
147 %-x-hours
meal versus fasting
95% CI lower
68 %-x-hours
adjusted difference
95% CI upper
225 %-x-hours
adjusted difference
P value
0.0003
difference
Source sentences
Summary
This decreased bioavailability led to lower relative suppression of serum CTX-I, with an AUC of the 4-h efficacy response of -91%-x-hours for those receiving a meal at 18.00 h, compared with -238%-x-hours for fasting subjects.
2 context sentences(design, population, supporting numbers)
Summary · context
The Dunnett-adjusted difference between these two treatment sequences was 147%-x-hours (95% CI 68, 225) (P= 0.0003).
Summary · context
A single-blind, randomized, partly placebo-controlled study was conducted in 36 healthy postmenopausal female volunteers aged 62-74 years.
Report a problemFND-1937131404
05HumanRandomized controlled trialEfficacy outcome
In postmenopausal women, salmon calcitonin efficacy AUC was comparable with a meal 10 min after dosing and fasting.
In plain wordsIn postmenopausal women, salmon calcitonin effects on the bone resorption marker were comparable with fasting and a meal 10 minutes after dosing.
Peptide
Calcitonin-salmon
Outcome
Not applicableCTX-I suppression AUC with postdose meal
Study
n: not reported in source
Comparator
Fasting
Outcome group
Bone and joint · Musculoskeletal
Studied dose
0.8 mg · oralAs given in this study (human).
Source sentences
Summary
The AUC was comparable among fasting subjects and those consuming a meal 10 min after dosing.
2 context sentences(design, population, supporting numbers)
Summary · context
This decreased bioavailability led to lower relative suppression of serum CTX-I, with an AUC of the 4-h efficacy response of -91%-x-hours for those receiving a meal at 18.00 h, compared with -238%-x-hours for fasting subjects.
Summary · context
A single-blind, randomized, partly placebo-controlled study was conducted in 36 healthy postmenopausal female volunteers aged 62-74 years.
Report a problemFND-1937131405

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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