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Study · Animal study (in vivo) · rat · 2009

5 results

[Effect of semax and mexidol on brain ischemia models in rats].

Iasnetsov VV, Voronina TA

Eksperimental'naia i klinicheskaia farmakologiia1 Jan 2009

PMID19334516 (opens in a new tab)PepBankPUB-19334516
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with brain ischemia from bilateral common carotid artery ligation, semax reduced neurological deficiency.

    In plain wordsIn rats with induced brain ischemia, semax reduced neurological deficits.

    Peptide
    Semax
    Outcome
    DecreaseNeurological deficit after bilateral carotid ligation
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    semax and mexidol significantly reduced neurological deficiency and increased the survival in rats with model brain ischemia induced by the bilateral ligation of common carotid arteries.
    1 context sentence
    Summary · context
    in rats with model brain ischemia induced by the bilateral ligation of common carotid arteries.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with brain ischemia from bilateral common carotid artery ligation, semax increased survival.

    In plain wordsIn rats with induced brain ischemia, semax increased survival.

    Peptide
    Semax
    Outcome
    IncreaseSurvival after bilateral carotid ligation
    Study

    ratn: not reported in source

    Outcome group
    Mortality · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    semax and mexidol significantly reduced neurological deficiency and increased the survival in rats with model brain ischemia induced by the bilateral ligation of common carotid arteries.
    1 context sentence
    Summary · context
    in rats with model brain ischemia induced by the bilateral ligation of common carotid arteries.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with brain ischemia, the effect of semax decreased with increasing dose over 0.3 to 1.2 mg/kg per day.

    In plain wordsIn rats with induced brain ischemia, the effect of semax became smaller as the dose rose.

    Peptide
    Semax
    Outcome
    DecreaseDose-effect relationship of semax
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0.3 to 1.2 mg/kg per dayAs given in this study (rat).

    Source sentences

    Summary
    Mexidol exhibited a linear dose-effect relationship (in a range of doses from 30 to 120 mg/kg per day), while the effect of semax decreased with increasing dose (in a dose range from 0.3 to 1.2 mg/kg per day).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with brain ischemia from gravitation overload, preventive semax courses reduced neurologic deficiency.

    In plain wordsIn rats with brain ischemia from gravitational overload, preventive semax courses reduced neurological deficits.

    Peptide
    Semax
    Outcome
    DecreaseNeurological deficit after gravitation overload
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Preventive course administration of semax and mexidol considerably reduced neurologic deficiency and amnesia in a step-down passive avoidance situation in rats with model brain ischemia caused by gravitation overload.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with brain ischemia from gravitation overload, preventive semax courses reduced amnesia in a step-down passive avoidance test.

    In plain wordsIn rats with brain ischemia from gravitational overload, preventive semax courses reduced memory loss in a passive avoidance test.

    Peptide
    Semax
    Outcome
    DecreaseAmnesia in step-down passive avoidance after gravitation overload
    Study

    ratn: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Preventive course administration of semax and mexidol considerably reduced neurologic deficiency and amnesia in a step-down passive avoidance situation in rats with model brain ischemia caused by gravitation overload.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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