In rats, intermittent PTH shifted the osteoprotegerin/RANKL balance toward hard tissue repair during late periodontal repair.
In plain wordsIn rats, intermittent PTH shifted bone repair regulators toward hard tissue repair compared with sham injections.
- Peptide
- Teriparatide (PTH 1-34)
- Outcome
- MixedOsteoprotegerin/RANKL balance
- Study
ratn: not reported in source
Tooth root resorption and periodontal repair- Comparator
- Sham injections
- Outcome group
- Bone and joint · Musculoskeletal
- Studied dose
- Dose not stated · systemic · up to 70 daysAs given in this study (rat).
Source sentences
The balance of these key regulators of bone remodeling was demonstrated to be shifted in favor of hard tissue repair by intermittent PTH administration, which was demonstrated to exert anabolic effects in several cell culture and animal experiments as well as in humans, in the late phase of repair.
1 context sentence(design, population, supporting numbers)
This study examined the histological changes and possible effects of intermittent parathyroid hormone (PTH) (1-34) treatment during the early and late phase of periodontal repair in a rat model of tooth root resorption.