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Study · Animal study (in vivo) · dog · 2009

6 results

The effect of growth hormone releasing peptide-2 on upper gastrointestinal contractile activity and food intake in conscious dogs.

Kudoh K, Shibata C, Funayama Y, Fukushima K, Ueno T, Hayashi K, Inui A, Bowers CY, Sasaki I

Journal of gastroenterology7 Mar 2009Cited by 6 (Europe PMC)

PMID19271111 (opens in a new tab)DOI10.1007/s00535-009-0025-y (opens in a new tab)PepBankPUB-19271111
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In neurally intact dogs in the interdigestive state, GHRP‑2 did not evoke gastrointestinal contractions.

    In plain wordsIn dogs not recently fed, GHRP‑2 did not cause gut contractions.

    Peptide
    GHRP-2
    Outcome
    No significant changeContractions in the interdigestive state
    Study

    dogn = 5

    conscious dogs with strain gauge force transducers
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    0.5-10 microg/kg · intravenousAs given in this study (dog).

    Source sentences

    Summary
    GHRP-2 did not evoke gastrointestinal contractions in the interdigestive state.
    1 context sentence
    Summary · context
    Five neurally intact dogs and five dogs with vagotomy and pyloroplasty were equipped with strain gauge force transducers on the stomach, duodenum and jejunum.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In neurally intact dogs, GHRP‑2 induced contractile inhibition of the upper gut that lasted 2-3 min.

    In plain wordsIn dogs, GHRP‑2 briefly slowed gut contractions for 2-3 minutes.

    Peptide
    GHRP-2
    Outcome
    DecreasePostprandial contractile inhibition in neurally intact dogs
    Study

    dogn = 5

    conscious dogs with strain gauge force transducers
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    0.5-10 microg/kg · intravenousAs given in this study (dog).

    Measurements

    Duration of contractile inhibition
    2 to 3 min
    neurally intact dogs

    Source sentences

    Summary
    GHRP-2 induced contractile inhibition continuing for 2-3 min in neurally intact dogs and dogs with vagotomy.
    1 context sentence
    Summary · context
    Five neurally intact dogs and five dogs with vagotomy and pyloroplasty were equipped with strain gauge force transducers on the stomach, duodenum and jejunum.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In dogs with vagotomy, GHRP‑2 induced contractile inhibition of the upper gut that lasted 2-3 min.

    In plain wordsIn dogs with the vagus nerve cut, GHRP‑2 still briefly slowed gut contractions for 2-3 minutes.

    Peptide
    GHRP-2
    Outcome
    DecreasePostprandial contractile inhibition in vagotomised dogs
    Study

    dogn = 5

    conscious dogs with strain gauge force transducers
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    0.5-10 microg/kg · intravenousAs given in this study (dog).

    Measurements

    Duration of contractile inhibition
    2 to 3 min
    dogs with vagotomy

    Source sentences

    Summary
    GHRP-2 induced contractile inhibition continuing for 2-3 min in neurally intact dogs and dogs with vagotomy.
    1 context sentence
    Summary · context
    Five neurally intact dogs and five dogs with vagotomy and pyloroplasty were equipped with strain gauge force transducers on the stomach, duodenum and jejunum.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In dogs, alpha- and alpha(2)-blockers reversed the contractile inhibition caused by GHRP‑2.

    In plain wordsIn dogs, drugs that block alpha receptors undid the gut-slowing effect of GHRP‑2.

    Peptide
    GHRP-2
    Outcome
    Not applicableReversal of GHRP-2 contractile inhibition by alpha-blockers
    Study

    dogn = 5

    conscious dogs with strain gauge force transducers
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    0.5-10 microg/kg · intravenousAs given in this study (dog).

    Source sentences

    Summary
    This inhibitory effect was reversed by the alpha- and alpha(2)-blockers.
    1 context sentence
    Summary · context
    Five neurally intact dogs and five dogs with vagotomy and pyloroplasty were equipped with strain gauge force transducers on the stomach, duodenum and jejunum.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In neurally intact dogs, GHRP‑2 given just before feeding increased food intake.

    In plain wordsIn dogs, GHRP‑2 given just before feeding made them eat more.

    Peptide
    GHRP-2
    Outcome
    IncreaseFood intake in neurally intact dogs
    Study

    dogn = 5

    conscious dogs with strain gauge force transducers
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intravenousAs given in this study (dog).

    Source sentences

    Summary
    GHRP-2 increased food intake in neurally intact dogs, but not in dogs with vagotomy.
    2 context sentences
    Summary · context
    GHRP-2 was also administered immediately before feeding in each group, and its effect on food intake was assessed.
    Summary · context
    Five neurally intact dogs and five dogs with vagotomy and pyloroplasty were equipped with strain gauge force transducers on the stomach, duodenum and jejunum.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In dogs with vagotomy, GHRP‑2 given just before feeding did not increase food intake.

    In plain wordsIn dogs with the vagus nerve cut, GHRP‑2 did not make them eat more.

    Peptide
    GHRP-2
    Outcome
    No significant changeFood intake in vagotomised dogs
    Study

    dogn = 5

    conscious dogs with strain gauge force transducers
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intravenousAs given in this study (dog).

    Source sentences

    Summary
    GHRP-2 increased food intake in neurally intact dogs, but not in dogs with vagotomy.
    2 context sentences
    Summary · context
    GHRP-2 was also administered immediately before feeding in each group, and its effect on food intake was assessed.
    Summary · context
    Five neurally intact dogs and five dogs with vagotomy and pyloroplasty were equipped with strain gauge force transducers on the stomach, duodenum and jejunum.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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