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Study · Randomized controlled trial · n = 25 · 2009

6 results

A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder.

Guastella AJ, Howard AL, Dadds MR, Mitchell P, Carson DS

Psychoneuroendocrinology25 Feb 2009Cited by 259 (Europe PMC)

PMID19246160 (opens in a new tab)DOI10.1016/j.psyneuen.2009.01.005 (opens in a new tab)PepBankPUB-19246160
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In adults with social anxiety disorder, oxytocin given with exposure therapy improved positive evaluations of appearance as sessions progressed versus placebo.

    In plain wordsIn adults with social anxiety, oxytocin with exposure therapy improved how positively people rated their appearance, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreasePositive evaluation of appearance during exposure sessions
    Study

    n = 25

    Comparator
    Placebo plus exposure therapy
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Participants administered with oxytocin showed improved positive evaluations of appearance and speech performance as exposure treatment sessions progressed.
    1 context sentence
    Summary · context
    In a randomized, double-blind, placebo-controlled trial, we administered 24 IU of oxytocin or a placebo in combination with exposure therapy to twenty-five participants who met primary diagnosis for SAD.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In adults with social anxiety disorder, oxytocin given with exposure therapy improved positive evaluations of speech performance as sessions progressed versus placebo.

    In plain wordsIn adults with social anxiety, oxytocin with exposure therapy improved how positively people rated their speech, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreasePositive evaluation of speech performance during exposure sessions
    Study

    n = 25

    Comparator
    Placebo plus exposure therapy
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Participants administered with oxytocin showed improved positive evaluations of appearance and speech performance as exposure treatment sessions progressed.
    1 context sentence
    Summary · context
    In a randomized, double-blind, placebo-controlled trial, we administered 24 IU of oxytocin or a placebo in combination with exposure therapy to twenty-five participants who met primary diagnosis for SAD.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In adults with social anxiety disorder, oxytocin did not improve overall treatment outcome from exposure therapy versus placebo.

    In plain wordsIn adults with social anxiety, oxytocin did not improve the overall result of exposure therapy compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeOverall treatment outcome from exposure therapy
    Study

    n = 25

    Comparator
    Placebo plus exposure therapy
    Outcome group
    Overall treatment effect · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    These effects did not generalize to improve overall treatment outcome from exposure therapy.
    1 context sentence
    Summary · context
    In a randomized, double-blind, placebo-controlled trial, we administered 24 IU of oxytocin or a placebo in combination with exposure therapy to twenty-five participants who met primary diagnosis for SAD.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In adults with social anxiety disorder, symptom severity reduction after exposure therapy was similar with oxytocin and placebo.

    In plain wordsIn adults with social anxiety, symptoms fell by a similar amount with oxytocin and with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeSymptom severity reduction after treatment
    Study

    n = 25

    Comparator
    Placebo plus exposure therapy
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Participants who received oxytocin or placebo reported similar levels of symptom reduction following treatment across symptom severity, dysfunctional cognition, and life-impairment measures.
    1 context sentence
    Summary · context
    In a randomized, double-blind, placebo-controlled trial, we administered 24 IU of oxytocin or a placebo in combination with exposure therapy to twenty-five participants who met primary diagnosis for SAD.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In adults with social anxiety disorder, reduction in dysfunctional cognition after exposure therapy was similar with oxytocin and placebo.

    In plain wordsIn adults with social anxiety, unhelpful thinking fell by a similar amount with oxytocin and with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeDysfunctional cognition reduction after treatment
    Study

    n = 25

    Comparator
    Placebo plus exposure therapy
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Participants who received oxytocin or placebo reported similar levels of symptom reduction following treatment across symptom severity, dysfunctional cognition, and life-impairment measures.
    1 context sentence
    Summary · context
    In a randomized, double-blind, placebo-controlled trial, we administered 24 IU of oxytocin or a placebo in combination with exposure therapy to twenty-five participants who met primary diagnosis for SAD.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In adults with social anxiety disorder, reduction in life impairment after exposure therapy was similar with oxytocin and placebo.

    In plain wordsIn adults with social anxiety, impact on daily life fell by a similar amount with oxytocin and with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeLife-impairment reduction after treatment
    Study

    n = 25

    Comparator
    Placebo plus exposure therapy
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Participants who received oxytocin or placebo reported similar levels of symptom reduction following treatment across symptom severity, dysfunctional cognition, and life-impairment measures.
    1 context sentence
    Summary · context
    In a randomized, double-blind, placebo-controlled trial, we administered 24 IU of oxytocin or a placebo in combination with exposure therapy to twenty-five participants who met primary diagnosis for SAD.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 1NCT03060031

Effects of Intranasal Oxytocin Administration on Social Influence Effects on Pain

University of Colorado, Bouldern = 5121 Jun 2017 to 1 Apr 2019

Pain

Trial pageClinicalTrials.govUpdated 25 Jun 2019

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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