Noopept stimulates the expression of NGF and BDNF in rat hippocampus.

Ostrovskaya RU, Gudasheva TA, Zaplina AP, Vahitova JV, Salimgareeva MH, Jamidanov RS, Seredenin SB

Bulletin of experimental biology and medicine1 Sept 2008Cited by 12 (Europe PMC)

PMID19240853DOI10.1007/s10517-008-0297-xPepBankPUB-19240853

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats, cortical NGF mRNA expression was below control after single Noopept administration.
In plain wordsIn rats, a single Noopept administration reduced cortical NGF gene expression compared with control.
Peptide
Noopept (omberacetam)
Outcome
DecreaseCortical NGF mRNA after single administration
Study
ratn: not reported in source
Comparator
Control
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Expression of the studied neurotropic factors in the cerebral cortex was below the control after single administration of Noopept, while chronic administration caused a slight increase in BDNF expression.
2 context sentences(design, population, supporting numbers)
Summary · context
We studied the effect of original dipeptide preparation Noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111) with nootropic and neuroprotective properties on the expression of mRNA for neurotropic factors NGF and BDNF in rat hippocampus.
Summary · context
Expression of NGF and BDNF mRNA in the cerebral cortex and hippocampus was studied by Northern blot analysis.
Report a problemFND-1924085301
02AnimalAnimal study (in vivo)Mechanism
In rats, cortical BDNF mRNA expression was below control after single Noopept administration.
In plain wordsIn rats, a single Noopept administration reduced cortical BDNF gene expression compared with control.
Peptide
Noopept (omberacetam)
Outcome
DecreaseCortical BDNF mRNA after single administration
Study
ratn: not reported in source
Comparator
Control
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Expression of the studied neurotropic factors in the cerebral cortex was below the control after single administration of Noopept, while chronic administration caused a slight increase in BDNF expression.
2 context sentences(design, population, supporting numbers)
Summary · context
We studied the effect of original dipeptide preparation Noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111) with nootropic and neuroprotective properties on the expression of mRNA for neurotropic factors NGF and BDNF in rat hippocampus.
Summary · context
Expression of NGF and BDNF mRNA in the cerebral cortex and hippocampus was studied by Northern blot analysis.
Report a problemFND-1924085302
03AnimalAnimal study (in vivo)Mechanism
In rats, chronic Noopept administration slightly increased cortical BDNF expression.
In plain wordsIn rats, chronic Noopept slightly increased cortical BDNF gene expression.
Peptide
Noopept (omberacetam)
Outcome
IncreaseCortical BDNF expression after chronic administration
Study
ratn: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · 28 daysAs given in this study (rat).
Source sentences
Summary
Expression of the studied neurotropic factors in the cerebral cortex was below the control after single administration of Noopept, while chronic administration caused a slight increase in BDNF expression.
3 context sentences(design, population, supporting numbers)
Summary · context
Taking into account the fact that pharmacological activity of Noopept is realized after both acute and chronic treatment, we studied the effect of single and long-term treatment (28 days) with this drug.
Summary · context
We studied the effect of original dipeptide preparation Noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111) with nootropic and neuroprotective properties on the expression of mRNA for neurotropic factors NGF and BDNF in rat hippocampus.
Summary · context
Expression of NGF and BDNF mRNA in the cerebral cortex and hippocampus was studied by Northern blot analysis.
Report a problemFND-1924085303
04AnimalAnimal study (in vivo)Mechanism
In rats, acute Noopept administration increased hippocampal NGF mRNA expression.
In plain wordsIn rats, acute Noopept increased hippocampal NGF gene expression.
Peptide
Noopept (omberacetam)
Outcome
IncreaseHippocampal NGF mRNA after acute administration
Study
ratn: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
In the hippocampus, expression of mRNA for both neurotrophins increased after acute administration of Noopept.
2 context sentences(design, population, supporting numbers)
Summary · context
We studied the effect of original dipeptide preparation Noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111) with nootropic and neuroprotective properties on the expression of mRNA for neurotropic factors NGF and BDNF in rat hippocampus.
Summary · context
Expression of NGF and BDNF mRNA in the cerebral cortex and hippocampus was studied by Northern blot analysis.
Report a problemFND-1924085304
05AnimalAnimal study (in vivo)Mechanism
In rats, acute Noopept administration increased hippocampal BDNF mRNA expression.
In plain wordsIn rats, acute Noopept increased hippocampal BDNF gene expression.
Peptide
Noopept (omberacetam)
Outcome
IncreaseHippocampal BDNF mRNA after acute administration
Study
ratn: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
In the hippocampus, expression of mRNA for both neurotrophins increased after acute administration of Noopept.
2 context sentences(design, population, supporting numbers)
Summary · context
We studied the effect of original dipeptide preparation Noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111) with nootropic and neuroprotective properties on the expression of mRNA for neurotropic factors NGF and BDNF in rat hippocampus.
Summary · context
Expression of NGF and BDNF mRNA in the cerebral cortex and hippocampus was studied by Northern blot analysis.
Report a problemFND-1924085305
06AnimalAnimal study (in vivo)Mechanism
In rats, chronic Noopept treatment did not produce tolerance to its neurotrophic effect.
In plain wordsIn rats, chronic Noopept did not produce tolerance to its effects on neurotrophic factors.
Peptide
Noopept (omberacetam)
Outcome
No significant changeTolerance to neurotrophic effect
Study
ratn: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · 28 daysAs given in this study (rat).
Source sentences
Summary
Chronic treatment with Noopept was not followed by the development of tolerance, but even potentiated the neurotrophic effect.
3 context sentences(design, population, supporting numbers)
Summary · context
Taking into account the fact that pharmacological activity of Noopept is realized after both acute and chronic treatment, we studied the effect of single and long-term treatment (28 days) with this drug.
Summary · context
We studied the effect of original dipeptide preparation Noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111) with nootropic and neuroprotective properties on the expression of mRNA for neurotropic factors NGF and BDNF in rat hippocampus.
Summary · context
Expression of NGF and BDNF mRNA in the cerebral cortex and hippocampus was studied by Northern blot analysis.
Report a problemFND-1924085306
07AnimalAnimal study (in vivo)Mechanism
In rats, chronic Noopept treatment potentiated its neurotrophic effect.
In plain wordsIn rats, chronic Noopept strengthened its effects on neurotrophic factors.
Peptide
Noopept (omberacetam)
Outcome
IncreasePotentiation of neurotrophic effect
Study
ratn: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · 28 daysAs given in this study (rat).
Source sentences
Summary
Chronic treatment with Noopept was not followed by the development of tolerance, but even potentiated the neurotrophic effect.
3 context sentences(design, population, supporting numbers)
Summary · context
Taking into account the fact that pharmacological activity of Noopept is realized after both acute and chronic treatment, we studied the effect of single and long-term treatment (28 days) with this drug.
Summary · context
We studied the effect of original dipeptide preparation Noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111) with nootropic and neuroprotective properties on the expression of mRNA for neurotropic factors NGF and BDNF in rat hippocampus.
Summary · context
Expression of NGF and BDNF mRNA in the cerebral cortex and hippocampus was studied by Northern blot analysis.
Report a problemFND-1924085307

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

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MeSH terms

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