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Study · In vitro (cells) · 2009

8 results

Upregulation of voltage-gated Na+ channels by long-term activation of the ghrelin-growth hormone secretagogue receptor in clonal GC somatotropes.

Dominguez B, Felix R, Monjaraz E

American journal of physiology. Endocrinology and metabolism17 Feb 2009Cited by 11 (Europe PMC)

PMID19223651 (opens in a new tab)DOI10.1152/ajpendo.90954.2008 (opens in a new tab)PepBankPUB-19223651
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In GC cells, GHRP‑6 increased sodium conductance.

    In plain wordsIn cells, GHRP‑6 increased sodium conductance.

    Peptide
    GHRP-6
    Outcome
    IncreaseSodium conductance
    Study

    n: not reported in source

    Tumoral somatotrope GC cell line
    Comparator
    Control culture conditions
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · 96 hAs given in this study.

    Source sentences

    Summary
    The effects of GHRP-6 were accompanied by an augment in conductance
    2 context sentences
    Summary · context
    In the current report, we investigated the effects of the growth hormone (GH) secretagogues ghrelin and GH-releasing peptide-6 (GHRP-6) on the regulation of the functional expression of voltage-gated Na(+) channels using the tumoral somatotrope GC cell line as a model.
    Summary · context
    Cells were cultured under control conditions or in presence of the GH secretagogues (GHS) for 96 h, and Na(+) currents (I(Na)) were characterized in whole cell patch-clamp experiments.
  2. 02LabIn vitro (cells)Mechanism

    In GC cells, GHRP‑6 did not change sodium current kinetics.

    In plain wordsIn cells, GHRP‑6 did not change sodium current kinetics.

    Peptide
    GHRP-6
    Outcome
    No significant changeSodium current kinetics
    Study

    n: not reported in source

    Tumoral somatotrope GC cell line
    Comparator
    Control culture conditions
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · 96 hAs given in this study.

    Source sentences

    Summary
    The effects of GHRP-6 were accompanied by an augment in conductance without changes in the kinetics and the voltage dependence of the currents, suggesting an increase in the number of channels in the cell membrane.
    2 context sentences
    Summary · context
    In the current report, we investigated the effects of the growth hormone (GH) secretagogues ghrelin and GH-releasing peptide-6 (GHRP-6) on the regulation of the functional expression of voltage-gated Na(+) channels using the tumoral somatotrope GC cell line as a model.
    Summary · context
    Cells were cultured under control conditions or in presence of the GH secretagogues (GHS) for 96 h, and Na(+) currents (I(Na)) were characterized in whole cell patch-clamp experiments.
  3. 03LabIn vitro (cells)Mechanism

    In GC cells, GHRP‑6 did not change sodium current voltage dependence.

    In plain wordsIn cells, GHRP‑6 did not change sodium current voltage dependence.

    Peptide
    GHRP-6
    Outcome
    No significant changeSodium current voltage dependence
    Study

    n: not reported in source

    Tumoral somatotrope GC cell line
    Comparator
    Control culture conditions
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · 96 hAs given in this study.

    Source sentences

    Summary
    The effects of GHRP-6 were accompanied by an augment in conductance without changes in the kinetics and the voltage dependence of the currents, suggesting an increase in the number of channels in the cell membrane.
    2 context sentences
    Summary · context
    In the current report, we investigated the effects of the growth hormone (GH) secretagogues ghrelin and GH-releasing peptide-6 (GHRP-6) on the regulation of the functional expression of voltage-gated Na(+) channels using the tumoral somatotrope GC cell line as a model.
    Summary · context
    Cells were cultured under control conditions or in presence of the GH secretagogues (GHS) for 96 h, and Na(+) currents (I(Na)) were characterized in whole cell patch-clamp experiments.

Studies that did not test the peptide alone5

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 04LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism

    In GC cells, GH secretagogues including GHRP‑6 increased sodium current density in a dose-dependent manner.

    In plain wordsIn cells, GH secretagogues including GHRP‑6 increased sodium current density with dose.

    Peptide
    GHRP-6
    Outcome
    IncreaseSodium current density
    Study

    n: not reported in source

    Tumoral somatotrope GC cell line
    Comparator
    Control culture conditions
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    GHS treatment significantly increased I(Na) density in a dose-dependent manner.
    2 context sentences
    Summary · context
    In the current report, we investigated the effects of the growth hormone (GH) secretagogues ghrelin and GH-releasing peptide-6 (GHRP-6) on the regulation of the functional expression of voltage-gated Na(+) channels using the tumoral somatotrope GC cell line as a model.
    Summary · context
    Cells were cultured under control conditions or in presence of the GH secretagogues (GHS) for 96 h, and Na(+) currents (I(Na)) were characterized in whole cell patch-clamp experiments.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 05LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism

    In GC cells, L-type calcium channel inhibition decreased sodium current density and prevented GH secretagogue effects.

    In plain wordsIn cells, calcium channel inhibition reduced sodium current density and prevented effects of GH secretagogues including GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    DecreaseSodium current density with L-type calcium channel inhibition
    Study

    n: not reported in source

    Tumoral somatotrope GC cell line
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Sustained inhibition of L-type Ca(2+) channel activity decreased I(Na) density and prevented the effects of the GHS
    2 context sentences
    Summary · context
    In the current report, we investigated the effects of the growth hormone (GH) secretagogues ghrelin and GH-releasing peptide-6 (GHRP-6) on the regulation of the functional expression of voltage-gated Na(+) channels using the tumoral somatotrope GC cell line as a model.
    Summary · context
    Cells were cultured under control conditions or in presence of the GH secretagogues (GHS) for 96 h, and Na(+) currents (I(Na)) were characterized in whole cell patch-clamp experiments.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 06LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism

    In GC cells, an L-channel agonist increased sodium current density and enhanced GHRP‑6 actions.

    In plain wordsIn cells, a calcium channel agonist increased sodium current density and enhanced GHRP‑6 effects.

    Peptide
    GHRP-6
    Outcome
    IncreaseSodium current density with L-channel agonist
    Study

    n: not reported in source

    Tumoral somatotrope GC cell line
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    whereas long-term exposure to an L-channel agonist increased I(Na) density and enhanced the actions of GHRP-6
    2 context sentences
    Summary · context
    In the current report, we investigated the effects of the growth hormone (GH) secretagogues ghrelin and GH-releasing peptide-6 (GHRP-6) on the regulation of the functional expression of voltage-gated Na(+) channels using the tumoral somatotrope GC cell line as a model.
    Summary · context
    Cells were cultured under control conditions or in presence of the GH secretagogues (GHS) for 96 h, and Na(+) currents (I(Na)) were characterized in whole cell patch-clamp experiments.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  4. 07LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism

    In GC cells, GHRP‑6 failed to enhance sodium channel expression during inhibition of protein kinases A, C or calcium/calmodulin-dependent kinase II.

    In plain wordsIn cells, kinase inhibitors prevented GHRP‑6 from increasing sodium channel expression.

    Peptide
    GHRP-6
    Outcome
    No significant changeSodium channel expression with kinase inhibitors
    Study

    n: not reported in source

    Tumoral somatotrope GC cell line
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Likewise, GHRP-6 failed to enhance Na(+) channel expression in the presence of membrane-permeable inhibitors of protein kinases A and C, as well as the Ca(2+)/calmodulin-dependent kinase II.
    2 context sentences
    Summary · context
    In the current report, we investigated the effects of the growth hormone (GH) secretagogues ghrelin and GH-releasing peptide-6 (GHRP-6) on the regulation of the functional expression of voltage-gated Na(+) channels using the tumoral somatotrope GC cell line as a model.
    Summary · context
    Cells were cultured under control conditions or in presence of the GH secretagogues (GHS) for 96 h, and Na(+) currents (I(Na)) were characterized in whole cell patch-clamp experiments.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  5. 08LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism

    In GC cells, a cAMP analog or PKC activator enhanced basal and GH secretagogue-induced GH secretion.

    In plain wordsIn cells, signaling activators increased basal and GH secretagogue-induced growth hormone release.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH secretion with signaling activators
    Study

    n: not reported in source

    Tumoral somatotrope GC cell line
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Conversely, treatment with a cAMP analog or a protein kinase C activator enhanced both basal and GHS-induced secretion of GH measured by enzyme-linked immunoassay
    2 context sentences
    Summary · context
    In the current report, we investigated the effects of the growth hormone (GH) secretagogues ghrelin and GH-releasing peptide-6 (GHRP-6) on the regulation of the functional expression of voltage-gated Na(+) channels using the tumoral somatotrope GC cell line as a model.
    Summary · context
    Cells were cultured under control conditions or in presence of the GH secretagogues (GHS) for 96 h, and Na(+) currents (I(Na)) were characterized in whole cell patch-clamp experiments.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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