Astrocytic plasticity and patterned oxytocin neuronal activity: dynamic interactions.

Wang YF, Hatton GI

The Journal of neuroscience : the official journal of the Society for Neuroscience1 Feb 2009Cited by 81 (Europe PMC)

PMID19211881PMCIDPMC3849422DOI10.1523/jneurosci.4669-08.2009PepBankPUB-19211881

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueMechanism
In supraoptic nucleus slices from lactating rats, oxytocin reduced GFAP expression.
In plain wordsIn lab tests on rat brain slices, oxytocin reduced levels of the astrocyte protein GFAP.
Peptide
Oxytocin
Outcome
DecreaseGFAP expression in brain slices
Study
ratn: not reported in source
supraoptic nucleus brain slices from lactating rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
OT, the dominant hormone mediating the MER, reduced GFAP expression in brain slices.
1 context sentence(design, population, supporting numbers)
Summary · context
We explored this issue using the supraoptic nucleus (SON) in lactating rats.
Report a problemFND-1921188101

Studies that did not test the peptide alone3

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

02LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In supraoptic nucleus slices, transient 12 mm K+ exposure reversed the oxytocin-induced reduction of GFAP expression.
In plain wordsIn lab tests on rat brain slices, a short potassium exposure reversed the GFAP drop caused by oxytocin.
Peptide
Oxytocin
Outcome
IncreaseGFAP expression with K+ exposure in the presence of oxytocin
Study
ratn: not reported in source
supraoptic nucleus brain slices from lactating rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
In the presence of OT, transient 12 mm K(+) exposure, simulating effects of synchronized bursts before the MER, reversed OT-reduced GFAP expression.
1 context sentence(design, population, supporting numbers)
Summary · context
We explored this issue using the supraoptic nucleus (SON) in lactating rats.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1921188102
03LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In supraoptic nucleus slices, tetanus toxin suppressed EPSCs but did not influence the oxytocin-induced reduction of GFAP.
In plain wordsIn lab tests on rat brain slices, tetanus toxin did not change the GFAP drop caused by oxytocin.
Peptide
Oxytocin
Outcome
No significant changeEffect of tetanus toxin on oxytocin-reduced GFAP
Study
ratn: not reported in source
supraoptic nucleus brain slices from lactating rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Tetanus toxin suppressed EPSCs but did not influence OT-reduced GFAP.
1 context sentence(design, population, supporting numbers)
Summary · context
We explored this issue using the supraoptic nucleus (SON) in lactating rats.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1921188103
04LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In supraoptic nucleus slices, protease inhibitors did not influence oxytocin-reduced GFAP images but blocked degradation of GFAP molecules.
In plain wordsIn lab tests on rat brain slices, protease inhibitors blocked GFAP breakdown but did not change the GFAP drop seen in images.
Peptide
Oxytocin
Outcome
No significant changeEffect of protease inhibitors on oxytocin-reduced GFAP
Study
ratn: not reported in source
supraoptic nucleus brain slices from lactating rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Protease inhibitors did not influence OT-reduced GFAP images but blocked the degradation of GFAP molecules.
1 context sentence(design, population, supporting numbers)
Summary · context
We explored this issue using the supraoptic nucleus (SON) in lactating rats.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1921188104

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 01:30 UTC
Study results updated
Version 1
9 Oct 2026, 02:51 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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