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Study · Not a test of the peptide alone · 2009

5 results

Hypothalamic-pituitary-adrenal axis assessment in healthy term neonatal foals utilizing a paired low dose/high dose ACTH stimulation test.

Hart KA, Heusner GL, Norton NA, Barton MH

Journal of veterinary internal medicine3 Feb 2008Cited by 29 (Europe PMC)

PMID19192152 (opens in a new tab)DOI10.1111/j.1939-1676.2008.00271.x (opens in a new tab)PepBankPUB-19192152
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cosyntropin.

  1. 01AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement

    In neonatal foals, the paired cosyntropin test design did not affect cortisol responses.

    In plain wordsIn foals, the paired cosyntropin test design did not change cortisol responses.

    Peptide
    Cosyntropin
    Outcome
    No significant changePaired protocol effect on cortisol response
    Study

    horsen = 20

    Healthy neonatal foals
    Comparator
    Saline instead of 10 microg cosyntropin before the high-dose test
    Outcome group
    Adrenal Function · Endocrine and hormones

    Source sentences

    Summary
    There was no effect of the paired ACTH stimulation test design itself on cortisol responses.
    3 context sentences
    Summary · context
    HPA axis function was assessed in 12 foals at birth and at 12-24, 36-48 hours, and 5-7 days of age.
    Summary · context
    At each age, basal cortisol and ACTH concentrations were measured and cortisol responses to 10 and 100 microg cosyntropin were assessed with a paired ACTH stimulation test protocol.
    Summary · context
    Eight additional 36-48-hour-old foals received saline instead of 10 microg cosyntropin in the same-paired ACTH stimulation test design.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  2. 02AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement

    In neonatal foals, cortisol responded significantly to 10 microg cosyntropin.

    In plain wordsIn foals, cortisol increased after 10 microg cosyntropin.

    Peptide
    Cosyntropin
    Outcome
    IncreaseCortisol response to low dose
    Study

    horsen = 12

    Healthy neonatal foals
    Comparator
    Basal cortisol
    Outcome group
    Adrenal Function · Endocrine and hormones

    Source sentences

    Summary
    A significant cortisol response to both the 10 and 100 microg doses of cosyntropin was observed in all foals.
    3 context sentences
    Summary · context
    HPA axis function was assessed in 12 foals at birth and at 12-24, 36-48 hours, and 5-7 days of age.
    Summary · context
    At each age, basal cortisol and ACTH concentrations were measured and cortisol responses to 10 and 100 microg cosyntropin were assessed with a paired ACTH stimulation test protocol.
    Summary · context
    Eight additional 36-48-hour-old foals received saline instead of 10 microg cosyntropin in the same-paired ACTH stimulation test design.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  3. 03AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement

    In foals, cortisol responses to 10 microg cosyntropin differed significantly across ages, with stronger responses in younger foals.

    In plain wordsIn foals, responses to 10 microg cosyntropin were stronger at younger ages.

    Peptide
    Cosyntropin
    Outcome
    MixedAge dependence of low-dose cortisol response
    Study

    horsen = 12

    Healthy neonatal foals
    Comparator
    Other age groups
    Outcome group
    Adrenal Function · Endocrine and hormones

    Source sentences

    Summary
    The magnitude of the cortisol response to both doses of cosyntropin was significantly different across age groups, with the most marked responses in younger foals.
    3 context sentences
    Summary · context
    HPA axis function was assessed in 12 foals at birth and at 12-24, 36-48 hours, and 5-7 days of age.
    Summary · context
    At each age, basal cortisol and ACTH concentrations were measured and cortisol responses to 10 and 100 microg cosyntropin were assessed with a paired ACTH stimulation test protocol.
    Summary · context
    Eight additional 36-48-hour-old foals received saline instead of 10 microg cosyntropin in the same-paired ACTH stimulation test design.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  4. 04AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement

    In foals, cortisol responses to 100 microg cosyntropin differed significantly across ages, with stronger responses in younger foals.

    In plain wordsIn foals, responses to 100 microg cosyntropin were stronger at younger ages.

    Peptide
    Cosyntropin
    Outcome
    MixedAge dependence of high-dose cortisol response
    Study

    horsen = 12

    Healthy neonatal foals
    Comparator
    Other age groups
    Outcome group
    Adrenal Function · Endocrine and hormones

    Source sentences

    Summary
    The magnitude of the cortisol response to both doses of cosyntropin was significantly different across age groups, with the most marked responses in younger foals.
    3 context sentences
    Summary · context
    HPA axis function was assessed in 12 foals at birth and at 12-24, 36-48 hours, and 5-7 days of age.
    Summary · context
    At each age, basal cortisol and ACTH concentrations were measured and cortisol responses to 10 and 100 microg cosyntropin were assessed with a paired ACTH stimulation test protocol.
    Summary · context
    Eight additional 36-48-hour-old foals received saline instead of 10 microg cosyntropin in the same-paired ACTH stimulation test design.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  5. 05AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement

    In neonatal foals, cortisol responded significantly to 100 microg cosyntropin.

    In plain wordsIn foals, cortisol increased after 100 microg cosyntropin.

    Peptide
    Cosyntropin
    Outcome
    IncreaseCortisol response to high dose
    Study

    horsen: not reported in source

    Healthy neonatal foals
    Comparator
    Basal cortisol
    Outcome group
    Adrenal Function · Endocrine and hormones

    Source sentences

    Summary
    A significant cortisol response to both the 10 and 100 microg doses of cosyntropin was observed in all foals.
    3 context sentences
    Summary · context
    HPA axis function was assessed in 12 foals at birth and at 12-24, 36-48 hours, and 5-7 days of age.
    Summary · context
    At each age, basal cortisol and ACTH concentrations were measured and cortisol responses to 10 and 100 microg cosyntropin were assessed with a paired ACTH stimulation test protocol.
    Summary · context
    Eight additional 36-48-hour-old foals received saline instead of 10 microg cosyntropin in the same-paired ACTH stimulation test design.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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