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Study · Animal study (in vivo) · rat · 2009

4 results

Amygdalar opioids modulate hypothalamic melanocortin-induced anorexia.

Beckman TR, Shi Q, Levine AS, Billington CJ

Physiology & behavior24 Dec 2008Cited by 28 (Europe PMC)

PMID19136019 (opens in a new tab)PMCIDPMC4284077 (opens in a new tab)DOI10.1016/j.physbeh.2008.12.007 (opens in a new tab)PepBankPUB-19136019
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In food-deprived rats, intra-PVN MTII partially blocked the increase in food intake caused by intra-CeA DAMGO.

    In plain wordsIn rats, Melanotan II injected into one brain area partly blocked the eating increase caused by DAMGO.

    Peptide
    Melanotan II
    Outcome
    DecreaseDAMGO-induced food intake (orexigenic effect)
    Study

    ratn: not reported in source

    Food-deprived male Sprague-Dawley rats
    Comparator
    DAMGO alone
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intra-PVN injectionAs given in this study (rat).

    Source sentences

    Summary
    In food-deprived male Sprague-Dawley rats, co-injected intra-PVN MTII partially blocked the orexigenic effect of co-injected intra-CeA DAMGO.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In food-deprived rats, intra-PVN MTII with intra-CeA naltrexone reduced food intake significantly more than either alone.

    In plain wordsIn rats, Melanotan II plus naltrexone reduced eating more than either one alone.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake, MTII plus intra-CeA naltrexone
    Study

    ratn: not reported in source

    Food-deprived male Sprague-Dawley rats
    Comparator
    MTII alone or naltrexone alone
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intra-PVN injectionAs given in this study (rat).

    Source sentences

    Summary
    Intra-CeA NTX co-injected with intra-PVN MTII reduced food intake significantly more than either alone.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, intra-PVN MTII induced c-Fos immunoreactivity in significantly more PVN neurons than in control animals.

    In plain wordsIn rats, Melanotan II switched on a brain-activity marker in more neurons of one brain area than in control animals.

    Peptide
    Melanotan II
    Outcome
    Increasec-Fos in PVN neurons, MTII
    Study

    ratn: not reported in source

    Food-deprived male Sprague-Dawley rats
    Comparator
    Control animals
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intra-PVN injectionAs given in this study (rat).

    Source sentences

    Summary
    Intra-PVN MTII induced c-Fos-IR in significantly more PVN neurons than observed in control animals.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, intra-PVN MTII with intra-CeA naltrexone significantly increased c-Fos in PVN neurons relative to control and naltrexone-only animals.

    In plain wordsIn rats, Melanotan II plus naltrexone raised a brain-activity marker in one brain area compared with control and naltrexone-only animals.

    Peptide
    Melanotan II
    Outcome
    Increasec-Fos in PVN neurons, MTII plus naltrexone
    Study

    ratn: not reported in source

    Food-deprived male Sprague-Dawley rats
    Comparator
    Control and intra-CeA naltrexone animals
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intra-PVN injectionAs given in this study (rat).

    Source sentences

    Summary
    Intra-CeA NTX co-injected with intra-PVN MTII induced c-Fos-IR significantly in PVN neurons relative to control and intra-CeA NTX animals.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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